Zhang Xiaohong, Zhang Yao, Li Shaojie, Liu Min, Lu Ying, He Mengyao, Sun Zhaoqing, Ma Mingfeng, Zheng Liqiang
Clinical Research Centre, The International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Nutr. 2024 May 15;11:1393552. doi: 10.3389/fnut.2024.1393552. eCollection 2024.
Previous animal experiments have demonstrated the potential of spermidine to mitigate glucose intolerance, insulin resistance, and hyperinsulinemia. However, there remains a scarcity of epidemiological evidence supporting these findings. Therefore, we aimed to elucidate the associations of serum spermidine with T2DM and FPG.
The cross-sectional study was conducted from June to August 2019 in the rural areas of Fuxin County, Liaoning Province, China. A total of 4,437 participants were included in the study. The serum spermidine was detected using high-performance liquid chromatography with a fluorescence detector. FPG was measured using the hexokinase method. T2DM was defined as participants with a FPG level of 7.0 mmol/L or greater, or self-reported diagnosis of diabetes by a doctor. Restricted cubic spline model and piecewise linear regression model were used to explore the associations of serum spermidine with T2DM and FPG, respectively.
The mean (SD) age of the participants was 59.3 (10.0) years, with 622 out of 4,437 participants being defined as T2DM. The serum spermidine in participants stratified by age and BMI categories was significantly different, with values of 0.006 and 0.001, respectively. Among all the participants, the association of serum spermidine with T2DM was J-shaped. The log (spermidine) was negatively associated with T2DM (OR = 0.68, 95% CI: 0.52 to 0.92, = 0.01) below the inflection point, while log (spermidine) was not significantly associated with T2DM (OR = 1.97, 95% CI: 0.93 to 4.15, = 0.07) above the inflection point. Among the participants without T2DM, the association of serum spermidine with FPG was inverted J-shaped. The log (spermidine) was positively associated with FPG ( = 0.13, 95% CI: 0.05 to 0.21, = 0.001) below the inflection point, while log (spermidine) was negatively associated with FPG ( = -0.29, 95% CI: -0.42 to -0.16, < 0.001) above the inflection point.
In conclusion, non-linear associations of serum spermidine with T2DM and FPG were found in the cross-sectional study in Chinese rural adults. This provided insights into the use of spermidine for the prevention of T2DM, highlighting the potential role in public health prevention strategies of spermidine.
先前的动物实验已证明亚精胺有减轻葡萄糖不耐受、胰岛素抵抗和高胰岛素血症的潜力。然而，支持这些发现的流行病学证据仍然匮乏。因此，我们旨在阐明血清亚精胺与2型糖尿病（T2DM）及空腹血糖（FPG）之间的关联。
本横断面研究于2019年6月至8月在中国辽宁省阜新县农村地区进行。共有4437名参与者纳入研究。血清亚精胺采用带荧光检测器的高效液相色谱法检测。FPG采用己糖激酶法测量。T2DM定义为FPG水平≥7.0 mmol/L的参与者，或医生自述诊断为糖尿病的参与者。分别采用受限立方样条模型和分段线性回归模型探讨血清亚精胺与T2DM及FPG之间的关联。
参与者的平均（标准差）年龄为59.3（10.0）岁，4437名参与者中有622名被定义为T2DM。按年龄和BMI类别分层的参与者血清亚精胺存在显著差异，P值分别为0.006和0.001。在所有参与者中，血清亚精胺与T2DM的关联呈J形。在拐点以下，log（亚精胺）与T2DM呈负相关（OR = 0.68，95%CI：0.52至0.92，P = 0.01），而在拐点以上，log（亚精胺）与T2DM无显著关联（OR = 1.97，95%CI：0.93至4.15，P = 0.07）。在无T2DM的参与者中，血清亚精胺与FPG的关联呈倒J形。在拐点以下，log（亚精胺）与FPG呈正相关（P = 0.13，95%CI：0.05至0.21，P = 0.001），而在拐点以上，log（亚精胺）与FPG呈负相关（P = -0.29，95%CI：-0.42至-0.16，P < 0.001）。
总之，在中国农村成年人的横断面研究中发现血清亚精胺与T2DM及FPG存在非线性关联。这为亚精胺用于预防T2DM提供了见解，凸显了亚精胺在公共卫生预防策略中的潜在作用。
