Department of Obstetrics, Chongqing Health Center for Women and Children, Chongqing, P.R. China.
Department of Pharmacy, Chongqing Health Center for Women and Children, Chongqing, P.R. China.
Int J Clin Pract. 2021 Oct;75(10):e14588. doi: 10.1111/ijcp.14588. Epub 2021 Jul 12.
Helicobacter pylori infection during pregnancy has some adverse effects, but its effects are still conflicting. This meta-analysis study was performed to assess the relationship between H pylori infection and adverse effects during pregnancy.
Through a systematic literature search up to August 2020, 31 studies included 16 887 pregnant females at baseline and reported a total of 5852 H pylori infection positive and 8196 H pylori infection negative pregnant females, were found recording relationships between H pylori infection and adverse effects during pregnancy. Odds ratio (OR) with 95% confidence intervals (CIs) was calculated between H pylori infection positive vs H pylori infection negative in adverse effects during pregnancy using the dichotomous methods with a random or fixed-effect model.
H pylori infection positive during pregnancy was significantly related to higher rate of preeclampsia (OR, 2.68; 95% CI, 2.02-3.56, P < .001), foetal growth restriction (OR, 1.45; 95% CI, 1.26-1.66, P < .001), gestational diabetes mellitus (OR, 2.63; 95% CI, 1.51-4.59, P < .001), and hyperemesis gravidarum (OR, 14.45; 95% CI, 10.24-20.38, P < .001) compared with H pylori infection negative. However, H pylori infection positive during pregnancy was not significantly correlated with spontaneous onset of labour (OR, 1.00; 95% CI, 0.83-1.21, P = .98) compared with H pylori infection negative.
H pylori infection may have an independent relationship with certain adverse effects during pregnancy. H pylori infection positive during pregnancy was significantly related to a higher rate of preeclampsia, foetal growth restriction, gestational diabetes mellitus, and hyperemesis gravidarum compared with H pylori infection negative. This relationship encouraged us to recommend screening and treating females for H pylori infection before and during pregnancy to avoid any possible complications.
怀孕期间感染幽门螺杆菌（H.pylori）会产生一些不良影响，但目前其影响仍存在争议。本荟萃分析旨在评估 H.pylori 感染与妊娠期间不良事件的关系。
通过系统文献检索，截至 2020 年 8 月，共纳入 31 项研究，共纳入 16887 名基线孕妇，共报告了 5852 例 H.pylori 感染阳性和 8196 例 H.pylori 感染阴性孕妇，记录了 H.pylori 感染与妊娠期间不良事件之间的关系。采用二项分类方法，以随机或固定效应模型，计算 H.pylori 感染阳性与 H.pylori 感染阴性孕妇妊娠不良事件的比值比（OR）及其 95%置信区间（CI）。
与 H.pylori 感染阴性孕妇相比，H.pylori 感染阳性孕妇先兆子痫（OR，2.68；95%CI，2.02-3.56，P<.001）、胎儿生长受限（OR，1.45；95%CI，1.26-1.66，P<.001）、妊娠期糖尿病（OR，2.63；95%CI，1.51-4.59，P<.001）和妊娠剧吐（OR，14.45；95%CI，10.24-20.38，P<.001）的发生率更高。然而，与 H.pylori 感染阴性孕妇相比，H.pylori 感染阳性孕妇自发性分娩的发生率（OR，1.00；95%CI，0.83-1.21，P=0.98）无显著差异。
H.pylori 感染可能与妊娠期间某些不良事件有关。与 H.pylori 感染阴性孕妇相比，H.pylori 感染阳性孕妇发生先兆子痫、胎儿生长受限、妊娠期糖尿病和妊娠剧吐的风险更高。这种关系促使我们建议在妊娠前和妊娠期间筛查和治疗 H.pylori 感染的女性，以避免任何可能的并发症。
