Boltin Doron, Perets Tsachi Tsadok, Elheiga Sami Abu, Sharony Asher, Niv Yaron, Shamaly Hussein, Dickman Ram
Department of Gastroenterology, Rabin Medical Center, Beilinson Campus, 39 Jabotinski Street, Petah Tikva, Israel 49100; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Gastroenterology Laboratory, Rabin Medical Center, Beilinson Campus, Petah Tikva, Israel.
Int J Infect Dis. 2014 Dec;29:292-5. doi: 10.1016/j.ijid.2014.10.005. Epub 2014 Oct 30.
Helicobacter pylori has been associated with hyperemesis gravidarum in some geographical regions. The prevalence of H. pylori in Arab Israeli women in the Upper Galilee and its association with hyperemesis gravidarum has not been studied previously. We aimed to examine if hyperemesis gravidarum is associated with H. pylori in this population.
Subjects with hyperemesis gravidarum carrying a singleton fetus were recruited prospectively. Women with an uncomplicated pregnancy served as controls. All patients underwent (13)C-urea breath testing to assess for H. pylori infection.
A total of 72 subjects, including 24 patients with hyperemesis gravidarum and 48 controls, aged 28.8±5.3 years, were included. H. pylori infection was identified in 75.0% (18/24) of cases and 60.4% (29/48) of controls (p=not significant). H. pylori infection did not correlate with age, fetal sex, or the number of previous pregnancies (p=not significant).
H. pylori does not seem to increase the likelihood of hyperemesis gravidarum in Arab Israeli women. However, given the high background prevalence of H. pylori in this population, a larger study is required to corroborate these findings. (MOH20110066).
在某些地理区域，幽门螺杆菌与妊娠剧吐有关。此前尚未对上加利利地区阿拉伯裔以色列妇女中幽门螺杆菌的患病率及其与妊娠剧吐的关联进行研究。我们旨在研究该人群中妊娠剧吐是否与幽门螺杆菌有关。
前瞻性招募怀有单胎胎儿的妊娠剧吐患者。妊娠无并发症的妇女作为对照。所有患者均接受¹³C-尿素呼气试验以评估幽门螺杆菌感染情况。
共纳入72名受试者，包括24例妊娠剧吐患者和48例对照，年龄为28.8±5.3岁。病例组中75.0%（18/24）、对照组中60.4%（29/48）检测出幽门螺杆菌感染（p值无统计学意义）。幽门螺杆菌感染与年龄、胎儿性别或既往妊娠次数均无相关性（p值无统计学意义）。
幽门螺杆菌似乎并未增加阿拉伯裔以色列妇女发生妊娠剧吐的可能性。然而，鉴于该人群中幽门螺杆菌的背景患病率较高，需要开展更大规模的研究来证实这些发现。（MOH20110066）
