School of Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Helicobacter. 2019 Apr;24(2):e12562. doi: 10.1111/hel.12562. Epub 2019 Jan 22.
To estimate the current evidence regarding the association between Helicobacter pylori infection during pregnancy and adverse pregnancy outcomes.
A systematic literature search for relevant publications was conducted using PubMed, EMBASE, Cochrane Library, and Web of science databases through November 17th, 2018. The pooled odds ratios (ORs) with their corresponding 95% confidence intervals (CIs) were selected as the effect size. Subgroup analysis and sensitivity analysis were performed.
Thirty-one studies with a total of 22 845 participants were identified. There was significant association of H pylori infection with preeclampsia (OR: 2.51; 95% CI: 1.88-3.34; P < 0.001), fetal growth restriction (OR: 2.28; 95% CI: 1.21-4.32; P = 0.01), gestational diabetes mellitus (OR: 2.03; 95% CI: 1.56-2.64; P < 0.001), spontaneous abortion (OR: 1.50; 95% CI: 1.05-2.14; P = 0.024), and birth defect (OR: 1.63; 95% CI: 1.05-2.54; P = 0.03). Sensitivity analysis showed the significant association between H pylori infection and low birthweight (OR: 1.59; 95% CI: 1.05-2.40; P = 0.03).
The present meta-analysis offers proof to support that H pylori infection during pregnancy can increase the risk on adverse pregnancy outcomes. Screening and treating for H pylori infection before pregnancy should be taken into account.
评估当前关于孕期幽门螺杆菌感染与不良妊娠结局之间关联的证据。
通过 PubMed、EMBASE、Cochrane 图书馆和 Web of Science 数据库对相关文献进行系统检索，检索时间截至 2018 年 11 月 17 日。选择汇总的优势比（OR）及其相应的 95%置信区间（CI）作为效应量。进行亚组分析和敏感性分析。
共确定了 31 项研究，总计 22845 名参与者。幽门螺杆菌感染与子痫前期（OR：2.51；95%CI：1.88-3.34；P<0.001）、胎儿生长受限（OR：2.28；95%CI：1.21-4.32；P=0.01）、妊娠期糖尿病（OR：2.03；95%CI：1.56-2.64；P<0.001）、自然流产（OR：1.50；95%CI：1.05-2.14；P=0.024）和出生缺陷（OR：1.63；95%CI：1.05-2.54；P=0.03）显著相关。敏感性分析显示，幽门螺杆菌感染与低出生体重之间存在显著关联（OR：1.59；95%CI：1.05-2.40；P=0.03）。
本荟萃分析提供了证据支持，表明孕期幽门螺杆菌感染会增加不良妊娠结局的风险。应考虑在怀孕前筛查和治疗幽门螺杆菌感染。
