Department of Veterinary Microbiology (Ghosh, Rubin), Department of Large Animal Medicine (Gow), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4; Canadian Integrated Program for Antimicrobial Resistance Surveillance, Centre for Foodborne Environmental Zoonotic Infectious Diseases, Public Health Agency of Canada, Laboratory for Foodborne Zoonoses, 160 Research Lane, Guelph, Ontario N1G 5B2 (Janecko, Agunos, Deckert, Reid-Smith).
Can Vet J. 2021 Jun;62(6):608-610.
Antimicrobial resistance surveillance targeting agricultural animals is practiced in many countries but does not often include media selective for cephalosporin resistance. Here, we compared the frequency of recovery of resistant using selective and non-selective media from the cecal contents of 116 chickens collected by the Canadian Integrated Program for Antimicrobial Resistance Surveillance (CIPARS). Third generation cephalosporin resistance was detected in 24 samples including 12, 10, and 2 on selective, non-selective, and both media, respectively. Isolates producing the CTX-M-1 ESBL were grown from 11 samples, 10 on selective medium only. Our results suggest that current surveillance approaches underestimate the true prevalence of resistance to critically important antimicrobials.
许多国家都在针对农业动物进行抗微生物药物耐药性监测，但通常不包括针对头孢菌素耐药性的选择性培养基。在这里，我们比较了从加拿大抗微生物药物耐药性监测综合计划（CIPARS）收集的 116 只鸡盲肠内容物中使用选择性和非选择性培养基回收耐药菌的频率。在包括 12、10 和 2 个样本的 24 个样本中检测到第三代头孢菌素耐药性，分别在选择性、非选择性和两种培养基上。11 个样本中生长出产 CTX-M-1 ESBL 的分离株，仅在选择性培养基上生长 10 个。我们的结果表明，目前的监测方法低估了对至关重要的抗菌药物的耐药性的真实流行率。
