St. Elisabeth Hospital, Tilburg, The Netherlands.
Emerg Infect Dis. 2011 Jul;17(7):1216-22. doi: 10.3201/eid1707.110209.
We determined the prevalence and characteristics of extended-spectrum β-lactamase (ESBL) genes of Enterobacteriaceae in retail chicken meat and humans in the Netherlands. Raw meat samples were obtained, and simultaneous cross-sectional surveys of fecal carriage were performed in 4 hospitals in the same area. Human blood cultures from these hospitals that contained ESBL genes were included. A high prevalence of ESBL genes was found in chicken meat (79.8%). Genetic analysis showed that the predominant ESBL genes in chicken meat and human rectal swab specimens were identical. These genes were also frequently found in human blood culture isolates. Typing results of Escherichia coli strains showed a high degree of similarity with strains from meat and humans. These findings suggest that the abundant presence of ESBL genes in the food chain may have a profound effect on future treatment options for a wide range of infections caused by gram-negative bacteria.
我们在荷兰确定了零售鸡肉和人类中肠杆菌科的扩展谱β-内酰胺酶（ESBL）基因的流行率和特征。收集了生肉样本，并在同一地区的 4 家医院同时进行了粪便携带情况的横断面调查。这些医院中含有 ESBL 基因的人类血液培养物也包括在内。鸡肉中发现 ESBL 基因的高流行率（79.8%）。遗传分析表明，鸡肉和人类直肠拭子标本中的主要 ESBL 基因相同。这些基因也经常在人类血液培养分离物中发现。大肠杆菌菌株的分型结果与来自肉类和人类的菌株高度相似。这些发现表明，食物链中大量存在 ESBL 基因可能对广泛的革兰氏阴性菌引起的感染的未来治疗选择产生深远影响。
