Highcroft Veterinary Referrals, 615 Wells Road, Whitchurch, BS14 9BE, Bristol, United Kingdom.
Can Vet J. 2021 Jun;62(6):611-616.
Cobalamin concentration is often assessed in clinical practice but little is known about the significance of hypercobalaminemia. The objective of this retrospective study was to identify the conditions associated with hypercobalaminemia in dogs and to investigate association with clinicopathological variables. Medical records of dogs having serum cobalamin measured between 2016 and 2018 were reviewed. One hundred sixty dogs were included and 47 (29%) showed hypercobalaminemia. Dogs with hypercobalaminemia had gastrointestinal (57%), hepatic (11%), neurological (11%), endocrine (9%), renal (4%), pancreatic (2%), and miscellaneous (6%) diseases. Overall, 11% had neoplasia. This distribution was not significantly different from that for hypocobalaminemic and normocobalaminemic dogs. There were significantly more dogs with hyperfolatemia in the hypercobalaminemia group. These results suggest that in clinical practice hypercobalaminemia is commonly identified in gastrointestinal and hepatic disease in dogs, but can also be seen with endocrine and neurological conditions. The frequency of hyperfolatemia alongside hypercobalaminemia may reflect common metabolic pathways.
钴胺素浓度在临床实践中经常进行评估，但对高钴胺素血症的意义知之甚少。本回顾性研究的目的是确定犬高钴胺素血症相关的条件，并研究与临床病理变量的相关性。回顾了 2016 年至 2018 年期间检测血清钴胺素的犬的病历。共纳入 160 只犬，其中 47 只（29%）出现高钴胺素血症。高钴胺素血症犬患有胃肠道疾病（57%）、肝脏疾病（11%）、神经疾病（11%）、内分泌疾病（9%）、肾脏疾病（4%）、胰腺疾病（2%）和其他疾病（6%）。总体而言，11%的犬患有肿瘤。这种分布与低钴胺素血症和正常钴胺素血症犬的分布无显著差异。高钴胺素血症组中高叶酸血症的犬明显更多。这些结果表明，在临床实践中，犬的胃肠道和肝脏疾病常伴有高钴胺素血症，但也可伴有内分泌和神经疾病。高钴胺素血症和高叶酸血症的同时发生可能反映了常见的代谢途径。
