Tantravahi R, Shipp M A, Greeley T A, Pavelka K, Bern M M, Rosenthal D S, Frei E
Cytogenetics Laboratory, Dana-Farber Cancer Institute, Boston, MA 02115.
Cancer Genet Cytogenet. 1988 Jan;30(1):83-90. doi: 10.1016/0165-4608(88)90095-7.
A translocation involving the short arm of chromosome #1 and the short arm of chromosome #7, [t(1;7)(p11;p11)] was present in four patients with myelodysplastic syndrome (MDS). Two of these patients had prior lymphoproliferative disorders and developed MDS following prolonged therapy with alkylating agents. One of the patients with prior therapy history has two additional independent abnormal clones: one with a partial deletion of the long arm of #7 and the other with t(1;7)(q21;q11). A third patient had a family history of leukemia in both the father and a brother, both of whom developed acute nonlymphocytic leukemia following an MDS phase. The last patient was an elderly woman with no predisposing features.
4例骨髓增生异常综合征（MDS）患者存在涉及1号染色体短臂和7号染色体短臂的易位，即[t(1;7)(p11;p11)]。其中2例患者既往有淋巴增殖性疾病，在接受烷化剂长期治疗后发生MDS。1例有既往治疗史的患者还有另外两个独立的异常克隆：一个是7号染色体长臂部分缺失，另一个是t(1;7)(q21;q11)。第3例患者的父亲和兄弟均有白血病家族史，二者在经历MDS阶段后均发展为急性非淋巴细胞白血病。最后1例患者是一位无诱发因素的老年女性。
