Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, China.
Front Immunol. 2021 Jun 18;12:699807. doi: 10.3389/fimmu.2021.699807. eCollection 2021.
Resistin, a cysteine-rich protein, expressed in adipocytes, was initially proposed as a link between obesity and diabetes in mice. In humans, resistin is considered to be a pro-inflammatory molecule expressed in immune cells, which plays a regulatory role in many chronic inflammatory diseases, metabolic diseases, infectious diseases, and cancers. However, increasing evidence shows that resistin functions as a host defense peptide of innate immunity, in terms of its wide-spectrum anti-microbial activity, modulation of immunity, and limitation of microbial product-induced inflammation. To date, the understanding of resistin participating in host defense mechanism is still limited. The review aims to summarize current knowledge about the biological properties, functions, and related mechanisms of resistin in host defense, which provides new insights into the pleiotropic biological function of resistin and yields promising strategies for developing new antimicrobial therapeutic agents.
抵抗素是一种富含半胱氨酸的蛋白质，在脂肪细胞中表达，最初被认为是肥胖与糖尿病之间在小鼠体内的联系。在人类中，抵抗素被认为是一种在免疫细胞中表达的促炎分子，在许多慢性炎症性疾病、代谢性疾病、传染病和癌症中发挥调节作用。然而，越来越多的证据表明，抵抗素作为先天免疫的宿主防御肽发挥作用，具有广谱抗微生物活性、调节免疫以及限制微生物产物诱导的炎症。迄今为止，对于抵抗素参与宿主防御机制的认识仍然有限。本综述旨在总结目前关于抵抗素在宿主防御中的生物学特性、功能和相关机制的知识，为抵抗素的多效生物学功能提供新的见解，并为开发新的抗微生物治疗药物提供有前景的策略。
