Mostafazadeh Mostafa, Haiaty Sanya, Rastqar Ali, Keshvari Mahtab
Immunology Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Biochemistry and Clinical Laboratories, Tabriz University of Medical Sciences, Tabriz, Iran.
Horm Metab Res. 2018 Jul;50(7):521-536. doi: 10.1055/a-0637-1975. Epub 2018 Jul 10.
Metabolic syndrome (MetS) has a collection of some abnormal and pathological conditions that cause many critical diseases. Resistin is one of the possible candidates for these pathologies but there are not enough data to prove if resistin has positive, neutral, or negative effects on one or some components of MetS. This review summarizes data about comparing the effects and contribution of resistin in initiation and progression of MetS components and also its different actions between human and other mammalians. This summarized data about the relationship of resistin and MetS components have been obtained from clinical researches and in some cases even animal studies. To find the relevant studies, the search in PubMed, Science Direct, and Scopus were performed. Human and animal studies on relationships between resistin and MetS (initiation and progression of components) were included in our search. In experiments reported among different human genetic groups as well as the patients with various disease such as diabetes, no significant correlation is shown between FBG and resistin level. Furthermore, this review shows that the results of correlation between resistin and TG, HDL, and central or abdominal obesity were inconsistent. These inconsistencies can arise from different sample size or genetic groups, gender, and also from experimental studies. Therefore, to obtain precise results systematic review and meta-analyses are required.
代谢综合征（MetS）是一系列导致许多严重疾病的异常和病理状况的集合。抵抗素是这些病理状况的可能候选因素之一，但尚无足够数据证明抵抗素对代谢综合征的一个或多个组成部分具有正向、中性或负向影响。本综述总结了有关比较抵抗素在代谢综合征各组成部分的起始和进展中的作用及贡献，以及其在人类和其他哺乳动物之间不同作用的数据。这些关于抵抗素与代谢综合征各组成部分关系的总结数据来自临床研究，在某些情况下甚至来自动物研究。为了找到相关研究，我们在PubMed、Science Direct和Scopus上进行了检索。我们的检索纳入了关于抵抗素与代谢综合征（各组成部分的起始和进展）之间关系的人类和动物研究。在不同人类遗传群体以及糖尿病等各种疾病患者中报告的实验中，空腹血糖（FBG）与抵抗素水平之间未显示出显著相关性。此外，本综述表明，抵抗素与甘油三酯（TG）、高密度脂蛋白（HDL）以及中心性或腹型肥胖之间的相关性结果并不一致。这些不一致可能源于不同的样本量、遗传群体、性别，也可能源于实验研究。因此，为了获得精确的结果，需要进行系统评价和荟萃分析。
