Saito T, Ikeda Y, Ito E, Miyano K, Kawauchi K, Yokoyama M, Sato Y
Dept. of Pediatrics, Hirosaki University School of Medicine.
Gan To Kagaku Ryoho. 1988 Jan;15(1):155-7.
A four-year-old boy with stage IV neuroblastoma was treated using the group study protocol of the Tohoku area for advanced neuroblastoma, consisting of DTIC, CPA, VCR, CDDP and VM-26, as a result of which had obtained complete remission. However, he had severe hemorrhagic cystitis after administration of CPA. He was treated with the usual therapy, but symptoms such as hematuria, pollakiuria and miction pain were not improved. We then tried bladder irrigation with prostaglandin E2. Half a milligram of PGE2 in 100 ml of physiological saline solution was instilled into the bladder and left in situ for 3 hours. The patient was free of symptoms on the day following the therapy. Local therapy with PGE2 thus seems very useful for cyclophosphamide-induced cystitis.
一名患有IV期神经母细胞瘤的4岁男孩，按照东北地区晚期神经母细胞瘤的分组研究方案进行治疗，该方案包括氮烯咪胺（DTIC）、环磷酰胺（CPA）、长春新碱（VCR）、顺铂（CDDP）和威猛（VM - 26），治疗后实现了完全缓解。然而，他在使用环磷酰胺后出现了严重的出血性膀胱炎。他接受了常规治疗，但血尿、尿频和排尿疼痛等症状并未改善。随后我们尝试用前列腺素E2进行膀胱冲洗。将100毫升生理盐水中含有的0.5毫克前列腺素E2注入膀胱，并在原位保留3小时。治疗后的第二天患者症状消失。因此，前列腺素E2局部治疗对于环磷酰胺诱导的膀胱炎似乎非常有效。
