Shurafa M, Shumaker E, Cronin S
J Urol. 1987 Jun;137(6):1230-1. doi: 10.1016/s0022-5347(17)44463-6.
We report a case of intractable cyclophosphamide-induced hemorrhagic cystitis. Conservative therapy, including suprapubic cystostomy with through-and-through bladder irrigation, failed to slow the bleeding. We then instilled 200 cc of a 0.7 mg. per cent solution of prostaglandin F2-alpha into the bladder for 4 hours daily. The bleeding ceased completely by the end of treatment 5 and the patient remains free of hematuria. There were no side effects noted during the 5 days of treatment. This form of therapy offers an effective, safe and easy alternative to more caustic bladder irrigants and methods of treatment.
我们报告一例难治性环磷酰胺诱导的出血性膀胱炎。保守治疗，包括耻骨上膀胱造瘘及膀胱持续冲洗，未能减缓出血。随后，我们每天向膀胱内灌注200 cc浓度为0.7 mg.%的前列腺素F2-α溶液，持续4小时。治疗5天后出血完全停止，患者血尿消失。治疗的5天期间未观察到副作用。这种治疗方式为更具腐蚀性的膀胱冲洗液和治疗方法提供了一种有效、安全且简便的替代方案。
