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PLoS One. 2020 May 26;15(5):e0233260. doi: 10.1371/journal.pone.0233260. eCollection 2020.
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Radiotherapy for oligometastatic cancer: a survey among radiation oncologists of Lombardy (AIRO-Lombardy), Italy.寡转移癌的放射治疗：意大利伦巴第（AIRO-Lombardy）放射肿瘤学家的一项调查。
Radiol Med. 2019 Apr;124(4):315-322. doi: 10.1007/s11547-018-0972-6. Epub 2018 Dec 15.
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一名接受多模式治疗的转移性神经内分泌前列腺癌长期幸存者：来自二代测序的遗传学考量

A long-term survivor of metastatic neuroendocrine prostate cancer treated with multimodal therapy: genetic consideration from next-generation sequencing.

作者信息

Hongo Hiroshi, Kosaka Takeo, Nakatsuka Seishi, Oya Mototsugu

机构信息

Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582 Japan.

Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan.

出版信息

Int Cancer Conf J. 2021 Apr 13;10(3):174-180. doi: 10.1007/s13691-021-00482-2. eCollection 2021 Jul.

DOI:10.1007/s13691-021-00482-2
PMID:34221827
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8206431/
Abstract

UNLABELLED

It is still unclear whether cell-free DNA (cfDNA) can replace solid-tissue biopsy. A 59-year-old man developed castration-resistant prostate cancer with a liver metastasis. We performed a liver biopsy and collected a cfDNA sample. Although he underwent radiofrequency ablation, tumors recurred and he was transferred to another hospital. We performed next-generation sequencing using DNA from the biopsy tissue and cfDNA. BRCA2 p.T3033fs and AURKA F31I were detected in both the biopsy tissue and the cfDNA. cfDNA may be useful as a liquid biopsy for monitoring the gene profile of aggressive prostate cancer.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1007/s13691-021-00482-2.

摘要

未标记

游离DNA（cfDNA）是否能够替代实体组织活检尚不清楚。一名59岁男性患去势抵抗性前列腺癌并伴有肝转移。我们进行了肝脏活检并采集了一份cfDNA样本。尽管他接受了射频消融治疗，但肿瘤复发，随后他被转至另一家医院。我们使用活检组织和cfDNA中的DNA进行了二代测序。在活检组织和cfDNA中均检测到BRCA2 p.T3033fs和AURKA F31I。cfDNA作为一种液体活检手段，可能有助于监测侵袭性前列腺癌的基因图谱。

补充信息

在线版本包含可在10.1007/s13691-021-00482-2获取的补充材料。