You Yang'en, Ge Shaozhong
Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Singapore, Singapore.
Angew Chem Int Ed Engl. 2021 Sep 13;60(38):20684-20688. doi: 10.1002/anie.202107405. Epub 2021 Aug 11.
Enantioselective cobalt-catalyzed one-pot hydrosilylation and hydroboration of terminal alkynes has been developed employing a cobalt catalyst generated from Co(acac) and (R,R)-Me-Ferrocelane. A variety of terminal alkynes undergo this asymmetric transformation, affording the corresponding gem-(borylsilyl)alkane products with high enantioselectivity (up to 98 % ee). This one-pot reaction combines (E)-selective hydrosilylation of alkynes and consecutive enantioselective hydroboration of (E)-vinylsilanes with one chiral cobalt catalyst. This protocol represents the most straightforward approach to access versatile chiral gem-(borylsilyl)alkanes from readily available alkynes with commercially available cobalt salt and chiral ligand.
利用由Co(acac)和(R,R)-Me-Ferrocelane生成的钴催化剂，开发了对映选择性钴催化的末端炔烃一锅法硅氢化和硼氢化反应。多种末端炔烃可进行这种不对称转化，以高对映选择性（高达98% ee）得到相应的偕（硼硅基）烷产物。该一锅法反应将炔烃的(E)-选择性硅氢化与(E)-乙烯基硅烷的连续对映选择性硼氢化结合在一种手性钴催化剂上。该方法是从易得的炔烃、市售钴盐和手性配体获得通用手性偕（硼硅基）烷的最直接途径。
