镍催化未活化末端烯烃的1,1-氨基硼化反应
Nickel-Catalyzed 1,1-Aminoborylation of Unactivated Terminal Alkenes.
作者信息
Talavera Laura, Freund Robert R A, Zhang Huihui, Wakeling Matthew, Jensen Mara, Martin Ruben
机构信息
Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain.
Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, c/Marcel·lí Domingo, 1, 43007 Tarragona, Spain.
出版信息
ACS Catal. 2023 Apr 10;13(8):5538-5543. doi: 10.1021/acscatal.3c00888. eCollection 2023 Apr 21.
Herein, we disclose a Ni-catalyzed 1,1-difunctionalization of unactivated terminal alkenes that enables the incorporation of two different heteroatom motifs across an olefin backbone, thus streamlining the access to α-aminoboronic acid derivatives from simple precursors. The method is characterized by its simplicity and generality across a wide number of coupling counterparts.
在此，我们披露了一种镍催化的未活化末端烯烃的1,1-双官能化反应，该反应能够在烯烃主链上引入两种不同的杂原子基团，从而简化了从简单前体合成α-氨基硼酸衍生物的方法。该方法的特点是简单易行，且适用于多种偶联反应物。
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