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人肺靶向性脂质体甲泼尼龙纳米抗体交联物的疗效和安全性的研发和评估。

Development and assessment of the efficacy and safety of human lung-targeting liposomal methylprednisolone crosslinked with nanobody.

机构信息

Department of Respiratory Medicine, School of Medicine, Shanghai Pulmonary Hospital, Tongji University, Shanghai, China.

Department of Respiratory Medicine, School of Medicine, Shanghai Pulmonary Hospital, Soochow University, Suzhou, China.

出版信息

Drug Deliv. 2021 Dec;28(1):1419-1431. doi: 10.1080/10717544.2021.1921073.

DOI:10.1080/10717544.2021.1921073
PMID:34223777
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8259875/
Abstract

Glucocorticoid (GC) hormone has been commonly used to treat systemic inflammation and immune disorders. However, the side effects associated with long-term use of high-dose GC hormone limit its clinical application seriously. GC hormone that can specifically target the lung might decrease the effective dosage and thus reduce GC-associated side effects. In this study, we successfully prepared human lung-targeting liposomal methylprednisolone crosslinked with nanobody (MPS-NSSLs-SPANb). Our findings indicate that MPS-NSSLs-SPANb may reduce the effective therapeutic dosage of MPS, achieve better efficacy, and reduce GC-associated side effects. In addition, MPS-NSSLs-SPANb showed higher efficacy and lower toxicity than conventional MPS.

摘要

糖皮质激素（GC）激素被广泛用于治疗全身炎症和免疫紊乱。然而，长期大剂量使用 GC 激素相关的副作用严重限制了其临床应用。具有肺部靶向性的 GC 激素可以减少有效剂量，从而降低 GC 相关的副作用。在这项研究中，我们成功制备了与人肺靶向性结合的纳米抗体交联的甲泼尼龙脂质体（MPS-NSSLs-SPANb）。我们的研究结果表明，MPS-NSSLs-SPANb 可能降低 MPS 的有效治疗剂量，实现更好的疗效，并减少 GC 相关的副作用。此外，MPS-NSSLs-SPANb 比常规 MPS 具有更高的疗效和更低的毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/134dd1d6a564/IDRD_A_1921073_F0009_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/4afd0bd12c0b/IDRD_A_1921073_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/f93756d55354/IDRD_A_1921073_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/6c9d329b15df/IDRD_A_1921073_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/163fbd871add/IDRD_A_1921073_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/19836b196bc5/IDRD_A_1921073_F0005_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/0bff303412c4/IDRD_A_1921073_F0006_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/badeb02da1c5/IDRD_A_1921073_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/ab327f867153/IDRD_A_1921073_F0008_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/134dd1d6a564/IDRD_A_1921073_F0009_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/4afd0bd12c0b/IDRD_A_1921073_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/f93756d55354/IDRD_A_1921073_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/6c9d329b15df/IDRD_A_1921073_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/163fbd871add/IDRD_A_1921073_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/19836b196bc5/IDRD_A_1921073_F0005_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/0bff303412c4/IDRD_A_1921073_F0006_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/badeb02da1c5/IDRD_A_1921073_F0007_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/ab327f867153/IDRD_A_1921073_F0008_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9dbe/8259875/134dd1d6a564/IDRD_A_1921073_F0009_C.jpg

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