葡萄糖酸洗必泰与单氟磷酸钠的体外相互作用。

Interaction between chlorhexidine digluconate and sodium monofluorophosphate in vitro.

作者信息

Barkvoll P, Rölla G, Bellagamba S

机构信息

Department of Pedodontics, Dental Faculty, University of Oslo, Norway.

出版信息

Scand J Dent Res. 1988 Feb;96(1):30-3. doi: 10.1111/j.1600-0722.1988.tb01404.x.

DOI:10.1111/j.1600-0722.1988.tb01404.x

PMID:3422503

Abstract

The aim of the present study was to investigate the compatibility of chlorhexidine digluconate and sodium monofluorophosphate since these agents are potential ingredients in future products in preventive dentistry. Varying combinations of chlorhexidine digluconate and sodium monofluorophosphate in water, covering the possible ranges of clinically relevant concentrations of both compounds, were made, incubated for 24 h and observed for precipitation of insoluble salts. The mixtures were analyzed for presence of free chlorhexidine and monofluorophosphate after incubation. The results showed that chlorhexidine digluconate and sodium monofluorophosphate are not compatible in clinically relevant concentrations. A chlorhexidine-monofluorophosphate salt of low solubility in water is presumably formed.

摘要

本研究的目的是调查葡萄糖酸洗必泰与单氟磷酸钠的相容性，因为这些药剂是未来预防牙科产品中的潜在成分。制备了葡萄糖酸洗必泰与单氟磷酸钠在水中的不同组合，涵盖了两种化合物临床相关浓度的可能范围，孵育24小时，并观察不溶性盐的沉淀情况。孵育后分析混合物中游离洗必泰和单氟磷酸的存在情况。结果表明，葡萄糖酸洗必泰与单氟磷酸钠在临床相关浓度下不相容。可能形成了一种在水中溶解度低的洗必泰-单氟磷酸盐盐。