Yadav Seema Roodmal, Kini Vineet Vaman, Padhye Ashvini
Post Graduate Student, Department of Periodontology, Mahatma Gandhi Mission's Dental College and Hospital , Kamothe, Navi Mumbai, Maharashtra, India .
Professor, Department of Periodontology, Mahatma Gandhi Mission's Dental College and Hospital , Kamothe, Navi Mumbai, Maharashtra, India .
J Clin Diagn Res. 2015 Sep;9(9):ZC69-74. doi: 10.7860/JCDR/2015/14587.6510. Epub 2015 Sep 1.
Chlorine dioxide (ClO2) is an oxidizing agent with known bactericidal, viricidal and fungicidal properties. Its efficacy in reducing the halitosis has been established by previous literature. However, data evaluating its antiplaque property is scarce. Chlorhexidine (CHX) is considered as the gold standard and an effective adjunctive to mechanical plaque removal. However, it is associated with few reversible side effects. Therefore a study was conducted to assess the antiplaque property of ClO2 containing mouthrinse against CHX mouthrinse.
To evaluate the efficacy of stabilized chlorine dioxide containing mouthrinse and CHX containing mouthrinse in inhibition of tongue coat accumulation and dental plaque formation using a four day plaque regrowth model clinically and microbiologically in a healthy dental cohort.
A Single Center, Randomized, Triple blinded, Microbiological clinical trial was conducted involving 25 healthy dental students volunteers (11 males, 14 females). Two commercially available mouthrinse: Mouthrinse A - Aqueous based ClO2 mouthrinse Freshchlor(®) and Mouthrinse B - Aqueous based 0.2% CHX mouthrinse Hexidine(®) were selected as the test products. Subjects were asked to rinse and gargle for 1 minute with the allocated mouthrinse under supervision after supragingival scaling, polishing and tongue coat removal. After four hours, smears were taken from the buccal mucosa and tooth surface. On the fifth day from baseline of four day non brushing plaque regrowth model the samples were again taken from buccal mucosa and tooth surface followed by recording of plaque scores by Rastogi Modification of Navy Plaque index, extent of tongue coat by Winkel's tongue coating index and measuring tongue coat wet weight in grams. The samples collected were subjected to microbial analysis and the results were expressed as colony forming units (CFUs) per sample.
The Data was analysed using SPSS 16.00 and presented using descriptive statistics. Independent t-test was used for the comparison between mouthrinse A groups & mouthrinse B group.
The plaque scores and Winkels tongue coat scores, wet tongue coat weight recorded on the fifth day after the use of the two mouthrinse didn't show a statistically significant difference. The CFU per sample from tooth and mucosa after four hours revealed low bacteria count with respect to mouthrinse B however the CFU obtained on the fifth day did not show a statistically significant difference between the two mouthrinse.
The clinical antiplaque efficacy of CHX and ClO2 mouthwash is comparable and so is the efficacy in reducing the oral bacterial load.
二氧化氯（ClO₂）是一种具有已知杀菌、杀病毒和杀真菌特性的氧化剂。先前的文献已证实其在减轻口臭方面的功效。然而，评估其抗牙菌斑特性的数据却很稀少。洗必泰（CHX）被视为金标准，是机械清除牙菌斑的有效辅助手段。然而，它会产生一些可逆的副作用。因此，开展了一项研究以评估含二氧化氯漱口水与含洗必泰漱口水的抗牙菌斑特性。
在一个健康牙科队列中，使用为期四天的牙菌斑再生长模型，从临床和微生物学角度评估含稳定二氧化氯漱口水和含洗必泰漱口水在抑制舌苔积聚和牙菌斑形成方面的功效。
进行了一项单中心、随机、三盲的微生物学临床试验，纳入25名健康牙科学生志愿者（11名男性，14名女性）。选择两种市售漱口水作为测试产品：漱口水A - 水性二氧化氯漱口水Freshchlor(®)，漱口水B - 0.2%水性洗必泰漱口水Hexidine(®)。在龈上洁治、抛光和清除舌苔后，受试者在监督下用分配的漱口水漱口1分钟。四小时后，从颊黏膜和牙齿表面取样。在为期四天的不刷牙牙菌斑再生长模型基线后的第五天，再次从颊黏膜和牙齿表面取样，随后用海军牙菌斑指数的Rastogi修正版记录牙菌斑分数，用温克尔舌苔指数记录舌苔范围，并用克为单位测量舌苔湿重。对收集的样本进行微生物分析，结果以每个样本的菌落形成单位（CFU）表示。
使用SPSS 16.00分析数据，并采用描述性统计进行呈现。使用独立t检验对漱口水A组和漱口水B组进行比较。
使用两种漱口水后第五天记录的牙菌斑分数、温克尔舌苔分数和舌苔湿重均未显示出统计学上的显著差异。四小时后牙齿和黏膜每个样本的CFU显示漱口水B的细菌计数较低，但第五天获得的CFU在两种漱口水之间未显示出统计学上的显著差异。
洗必泰和二氧化氯漱口水的临床抗牙菌斑功效相当，在降低口腔细菌载量方面的功效也相当。
