Salazar A
Facultad de Medicina Universidad Nacional Autonoma de Mexico.
Cleft Palate J. 1988 Jan;25(1):38-42.
Two studies were done to determine the ideal day to perform an intrauterine procedure and to explore maternal behavior toward repaired cleft lip offspring rats. The first study showed that the best time to create a surgical cleft lesion was on the 19th day of pregnancy. Thus, for the second study rat fetuses were operated in utero on the 19th day of gestation, and the pups were delivered by cesarean section. One group was obtained with a lesion resembling cleft lip and a second group with repair of such lesion. Nonoperated litter mates were used as a control group. Two animals of each type were placed inside a cage, and the order in which the mother retrieved them and carried them to the nest was noted. Statistical analysis showed that retrieving them was not at random. All controls and 14 out of 18 treated animals were retrieved, but only 4 out of 18 of the clefted group were retrieved.
进行了两项研究，以确定进行宫内手术的理想日期，并探究母鼠对唇裂修复后代大鼠的行为。第一项研究表明，制造手术性腭裂损伤的最佳时间是在怀孕第19天。因此，在第二项研究中，妊娠第19天对大鼠胎儿进行宫内手术，然后通过剖宫产分娩幼崽。一组形成类似唇裂的损伤，另一组修复该损伤。未手术的同窝幼崽用作对照组。每种类型的两只动物被放置在一个笼子里，记录母鼠找回它们并带回巢穴的顺序。统计分析表明，找回它们并非随机行为。所有对照组和18只经治疗动物中的14只被找回，但唇裂组的18只中只有4只被找回。
