Williams R S, Rao C V, Yussman M A
Department of Obstetrics and Gynecology, University of Louisville, Kentucky.
Fertil Steril. 1988 Mar;49(3):547-50.
CA-125 has been found to be mildly elevated in the serum of patients with advanced stages of endometriosis, but not with minimal endometriosis. Peritoneal fluid levels were measured in conjunction with serum levels in 12 consecutive patients with endometriosis and 12 consecutive normal controls. Apparent peritoneal fluid values were found to be 10-fold higher than serum levels, with no difference between the study groups (130 versus 106 U/ml, respectively). However, when peritoneal fluid was diluted to validate the assay system in peritoneal fluid, no sample of peritoneal fluid showed decreased binding with serial dilutions of 1:2, 1:5, and 1:10. At a dilution of 1:100, there was some decreased binding, but the level was 17-fold higher than expected. The source of this interference is unknown.
研究发现，在晚期子宫内膜异位症患者的血清中，CA - 125会轻度升高，但在轻度子宫内膜异位症患者中则不会。对12例连续的子宫内膜异位症患者和12例连续的正常对照者同时检测了血清和腹腔液中的CA - 125水平。结果发现，腹腔液中的CA - 125水平明显高于血清水平，约为血清水平的10倍，且研究组之间无差异（分别为130 U/ml和106 U/ml）。然而，当对腹腔液进行稀释以验证检测系统时，在1:2、1:5和1:10的系列稀释中，没有一份腹腔液样本显示结合力下降。在1:100的稀释度下，结合力有一定程度的下降，但仍比预期高17倍。这种干扰的来源尚不清楚。
