Antimicrobial and antioxidant activities of secondary metabolites from endophytic fungus (MGN23-3) associated to L.

This study was to evaluate the biological activity of the extract of isolated from leaves of . The volatile compounds from the crude extract were analysed by GC-MS which demonstrate that mellein and β-orcinaldehyde were are the major compounds. The best minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the extract was observed against Gram-positive bacteria, with a MIC of 15.6 μg/mL towards and MIC of 62.5 μg/mL towards and . MBC values of 31.25 μg/mL, 62.5 μg/mL, and 250 μg/mL were observed towards , , and , respectively. The cytotoxicity analyses showed CC of 115 μg/mL. The crude extract showed antioxidant activity by the DPPH, ABTS, and FRAP assays. Therefore, the extract of the endophytic fungus presented biotechnological potential as an antibacterial and antioxidant agent.