Antimicrobial and Antioxidant Activities of Endophytic Fungi Associated with (Bignoniaceae).

The endophytic fungal community of the Amazonian medicinal plant (Bignoniaceae) was evaluated based on the hypothesis that microbial communities associated with plant species in the Amazon region may produce metabolites with interesting bioactive properties. Therefore, the antimicrobial and antioxidant activities of the fungal extracts were investigated. A total of 107 endophytic fungi were grown in liquid medium and the metabolites were extracted with ethyl acetate. In the screening of fungal extracts for antimicrobial activity, the fungus identified as CF2-13 was the most promising, with activity against , , , , , , , , , and, especially, against and (MIC = 0.312 mg/mL). Screening for antioxidant potential using the DPPH elimination assay showed that the sp. CG1-7 endophyte extract exhibited potential activity with an EC of 11 µg/mL, which is equivalent to quercetin (8 µg/mL). The FRAP method confirmed the antioxidant potential of the fungal extracts. The presence of phenolic compounds and flavonoids in the active extracts was confirmed using TLC. These results indicate that two of the fungi isolated from exhibit significant antimicrobial and antioxidant potential.