Department of Obstetrics and Gynecology Topiwala National Medical College and BYL Nair Charitable Hospital, Mumbai, Maharashtra.
ICMR-National Institute for Research in Reproductive Health, Mumbai.
J Assoc Physicians India. 2021 Jan;69(1):16-18.
Reinfection/reactivation of SARS-CoV-2 has been a matter of great interest from the immunological and vaccine perspective. However, little is known about the clinical presentation of such reinfection/reactivation. We report a case series of 9 COVID-19 patients having experienced two clinically- and/or virologically-confirmed episodes of COVID-19.
Epidemiological and clinical characteristics of 9 healthcare workers (HCWs) with two episodes of SARS-CoV-2 are described.
The incidence of reinfection/reactivation amongst the HCWs was 2% (9 out of 491) with an average remission period of 66 days (range 43-78 days). Amongst the cases of reinfection 4/9 were asymptomatic in first episode were symptomatic in second episode. There is negative correlation between numbers of days the patients took to become SARS-CoV-2 negative by RT-CPR and/or clinically recover in the first episode and the second episode irrespective for the time spent in remission.
Shorter durations of SARS-COV-2 infection in the first episode are associated with longer time to recovery in the second episode in patients with re-infection/reactivation.
从免疫学和疫苗角度来看，SARS-CoV-2 的再感染/再激活一直是人们关注的焦点。然而，对于这种再感染/再激活的临床表现知之甚少。我们报告了 9 例 COVID-19 患者经历了两次临床和/或病毒学确诊的 COVID-19 发作的病例系列。
描述了 9 名有两期 SARS-CoV-2 发作的医护人员的流行病学和临床特征。
医护人员的再感染/再激活发生率为 2%（491 人中有 9 人），平均缓解期为 66 天（范围为 43-78 天）。在再感染病例中，有 4/9 人在第一次发作时无症状，第二次发作时出现症状。第一次发作中患者通过 RT-PCR 和/或临床恢复为 SARS-CoV-2 阴性的天数与第二次发作中恢复的天数之间存在负相关，而与缓解期的时间无关。
在再感染/再激活患者中，第一次 SARS-COV-2 感染的持续时间越短，第二次发作的恢复时间就越长。
