Srimati Kanuri Santhamma Center for Retina & Vitreous Diseases, L V Prasad Eye Institute, Hyderabad, India.
Uveitis and Ocular Immunology Services, L V Prasad Eye Institute, Hyderabad, India.
Ocul Immunol Inflamm. 2021 May 19;29(4):722-725. doi: 10.1080/09273948.2021.1938135. Epub 2021 Jul 6.
: Infection by the SARS-CoV2 virus results in an immune dysregulated state which can predispose to reactivation of Herpes viruses. This report describes the development of Acute Retinal Necrosis (ARN) in two patients who had recovered from SARS-CoV2 infection. Observational report of two consecutive patients who presented with ARN after having recovered from SARS-CoV-2 infection. Case 1 was a 5-year-old child with extensive peripheral necrotizing retinitis. Case 2 was a 61-year-old gentlemen with bilateral retinal detachment with sieve-like breaks and optic atrophy. Both patients had recovered from SARS- Cov-2 infection 1 month ago. PCR from vitreous sample of both patients was positive for Herpes simplex virus. Case 1 was treated with oral valacyclovir. Case 2 underwent surgery in both eyes for retinal detachment Immune dysregulation after COVID-19 infection can result in reactivation of herpesvirus and may lead to development of ARN.
SARS-CoV-2 病毒感染会导致免疫失调状态,从而使疱疹病毒重新激活。本报告描述了两例从 SARS-CoV-2 感染中康复的患者发生急性视网膜坏死 (ARN) 的情况。
对两例在 SARS-CoV-2 感染康复后出现 ARN 的连续患者进行观察性报告。
病例 1 为 5 岁儿童,表现为广泛的周边坏死性视网膜炎。病例 2 为 61 岁男性,双眼视网膜脱离伴筛状裂孔和视神经萎缩。两名患者均在 1 个月前从 SARS-CoV-2 感染中康复。两名患者的玻璃体样本 PCR 均为单纯疱疹病毒阳性。病例 1 接受了口服伐昔洛韦治疗。病例 2 双眼均接受了视网膜脱离手术。
COVID-19 感染后的免疫失调可能导致疱疹病毒重新激活,并可能导致 ARN 的发生。