Aliev M G, Rzaeva L V, Rybakova O I
Probl Endokrinol (Mosk). 1987 Sep-Oct;33(5):74-8.
The effect of chronic stress (electric stimulation) in the second half-period of pregnancy on the status of the hypophyseothyroid system of mother and her progeny was studied. Experiments were staged on 100 pregnant rats and their progeny aged 20 days, 1, 2, 3 and 6 mos. The content of thyroxine (T4), triiodothyronine (T3) and thyrotropic hormone (TTH) in the blood of mother (in the midterm and at the end of pregnancy) and progeny was determined by a radioimmunoassay. Chronic stress during pregnancy led to a decrease in the level of thyroid hormones by the end of pregnancy, the decrease being more significant than that in controls. In the progeny of experimental rats higher T4 content (as compared to that in controls) was accompanied by a lowered level of T3 indicating a decrease in the metabolism of thyroid hormones. These changes were most noticeable at early stages of development but were preserved till puberty. Thus chronic stress during pregnancy led to a decrease in the content of thyroid hormones in the mother's blood, an increase in thyroid function of progeny, and a decrease in its general thyroid status.
研究了孕期后半期慢性应激（电刺激）对母鼠及其后代垂体 - 甲状腺系统状态的影响。对100只怀孕大鼠及其20日龄、1个月、2个月、3个月和6个月大的后代进行了实验。通过放射免疫分析法测定了母鼠（孕期中期和末期）和后代血液中甲状腺素（T4）、三碘甲状腺原氨酸（T3）和促甲状腺激素（TTH）的含量。孕期慢性应激导致孕期结束时甲状腺激素水平下降，且下降幅度比对照组更显著。在实验大鼠的后代中，较高的T4含量（与对照组相比）伴随着较低的T3水平，表明甲状腺激素代谢降低。这些变化在发育早期最为明显，但一直持续到青春期。因此，孕期慢性应激导致母鼠血液中甲状腺激素含量降低，后代甲状腺功能增强，总体甲状腺状态降低。
