脂肪来源干细胞在卵巢癌进展、转移和化疗耐药中的作用。
Adipose-derived stem cells in ovarian cancer progression, metastasis, and chemoresistance.
机构信息
Department of Genetics, Genomics & Informatics, College of Medicine, the University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Department of Pathology and Laboratory Medicine, College of Medicine, the University of Tennessee Health Science Center, Memphis, TN 38163, USA.
出版信息
Exp Biol Med (Maywood). 2021 Aug;246(16):1810-1815. doi: 10.1177/15353702211023846. Epub 2021 Jul 6.
Abstract
Ovarian cancer is the deadliest gynecological malignancy due to its symptomless early stage, metastasis, and high recurrence rate. The tumor microenvironment contributes to the ovarian cancer progression, metastasis, and chemoresistance. Adipose-derived stem cell in the tumor microenvironment of ovarian cancer, as a key player, interacts with ovarian cancer cells to form the cancer-associated fibroblasts and cancer-associated adipocytes, and secretes soluble factors to activate tumor cell signaling, which can promote ovarian cancer metastasis and chemoresistance. We summarize in this review the recent progress in the studies of interactions between adipose-derived stem cell and ovarian cancer, thus, to provide some insight for ovarian cancer therapy through targeting adipose-derived stem cell.
摘要
卵巢癌是妇科恶性肿瘤中致死率最高的一种，这是由于其早期无症状、易转移和高复发率等特点所致。肿瘤微环境促进了卵巢癌的进展、转移和化疗耐药。脂肪来源的干细胞作为肿瘤微环境中的关键参与者，与卵巢癌细胞相互作用，形成癌相关成纤维细胞和癌相关脂肪细胞，并分泌可溶性因子激活肿瘤细胞信号，从而促进卵巢癌细胞转移和化疗耐药。我们总结了脂肪来源干细胞与卵巢癌相互作用的最新研究进展，以期为通过靶向脂肪来源干细胞治疗卵巢癌提供一些思路。
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