Coleman G L, Kanfer I, Haigh J M
Dermatologica. 1978;156(4):224-30. doi: 10.1159/000250920.
The blanching activities and hence bioavailabilities of the cream, ointment and fatty ointment preparations of Nerisone and Temetex (diflucortolone valerate 0.1%) were evaluated using an occluded and unoccluded blanching assay. These products were compared to Synalar ointment and cream (fluocinolone acetonide 0.025%), established topical corticosteroid preparations. Statistical analysis showed no significant differences between similar formulations of diflucortolone valerate. Significant differences were noted between diflucortolone valerate and fluocinolone acetonide preparations.
采用封包和非封包变白试验，对Nerisone和Temetex（戊酸二氟可龙0.1%）乳膏、软膏和脂肪性软膏制剂的变白活性及生物利用度进行了评估。将这些产品与已有的外用皮质类固醇制剂Synalar软膏和乳膏（醋酸氟轻松0.025%）进行比较。统计分析表明，戊酸二氟可龙类似制剂之间无显著差异。戊酸二氟可龙制剂和醋酸氟轻松制剂之间存在显著差异。
