Department of Chemistry, Bio-Inspired Materials Research Laboratory, Savitribai Phule Pune University (Formerly University of Pune), Ganeshkhind, Pune 411007, India.
J Nanosci Nanotechnol. 2021 Dec 1;21(12):6168-6182. doi: 10.1166/jnn.2021.19538.
Zinc oxide nanoparticles have been biosynthesized with the help of leaf and fruit extracts. ZnO nanoparticles were tested for antibacterial activity before and after calcination against Gram positive () as well as Gram negative micro-organisms () within the concentration range 0.625-10 mg/mL with the help of well diffusion technique. Higher antibacterial potential has been observed in ZnO nanoparticles synthesized using leaf extract in comparison with those synthesized using fruit extract. Increased antibacterial activity was observed before calcination as compared to after calcination. ZnO synthesized using leaf extract were observed to show significant antibacterial potential against along with before calcination as well as against after calcination. Similarly, ZnO nanoparticles synthesized using fruit extract exhibited antibacterial activity against and before calcination and against after calcination. Both the ZnO nanoparticles before and after calcination did not show any antibacterial activity against . Thus, ZnO nanoparticles can serve a dual purpose by its application as an antibacterial agent against susceptible micro-organisms as well as biocompatible carrier system for drug delivery applications in case of non-antibacterial properties by virtue of its inertness as well as easy disposal.
氧化锌纳米粒子已经在叶子和果实提取物的帮助下被生物合成。利用平板扩散法，在浓度范围为 0.625-10mg/mL 的情况下，研究了煅烧前后对革兰氏阳性（）和革兰氏阴性微生物（）的抗菌活性。使用叶提取物合成的 ZnO 纳米粒子比使用果提取物合成的 ZnO 纳米粒子具有更高的抗菌潜力。与煅烧后相比，煅烧前的抗菌活性更高。与煅烧前相比，用叶提取物合成的 ZnO 对 具有显著的抗菌潜力，对 也有一定的抗菌活性。同样，用果提取物合成的 ZnO 纳米粒子对 具有抗菌活性，对 也有一定的抗菌活性。煅烧前后的 ZnO 纳米粒子对 均没有抗菌活性。因此，氧化锌纳米粒子可以作为一种抗菌剂，对抗敏感微生物，同时也可以作为药物输送应用的生物相容性载体系统，因为它具有惰性和易于处理，即使没有抗菌性能也可以发挥作用。
