Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46202, USA; Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital, Beijing, China.
Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46202, USA.
Clin Liver Dis. 2021 Aug;25(3):483-492. doi: 10.1016/j.cld.2021.03.009. Epub 2021 May 26.
Alcohol-associated liver disease (ALD) is a consequence of excessive alcohol use. It comprises a spectrum of histopathologic changes ranging from simple steatosis, steatohepatitis, and cirrhosis to hepatocellular carcinoma. The public health impact of ALD is growing because of an increase in the prevalence and incidence of ALD in parallel with liver transplant and mortalities. There are multiple factors involved in the pathogenesis and progression of ALD. Reducing alcohol consumption is the cornerstone of ALD management. The efforts to reduce excessive alcohol use at the individual and population levels are urgently needed to prevent adverse outcomes from ALD.
酒精相关性肝病（ALD）是过量饮酒的后果。它包含一系列组织病理学变化，从单纯性脂肪变性、脂肪性肝炎和肝硬化到肝细胞癌不等。由于ALD 的患病率和发病率与肝移植和死亡率平行增加，ALD 的公共卫生影响正在增加。ALD 的发病机制和进展涉及多种因素。减少酒精摄入是 ALD 管理的基石。迫切需要在个人和人群层面上减少过量饮酒，以防止 ALD 的不良后果。
