Department of Pathology, Dongguan People's Hospital (Affiliated Dongguan People's Hospital, Southern Medical University), Dongguan, China.
Department of Pathology, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
Biosci Rep. 2021 Jul 30;41(7). doi: 10.1042/BSR20211175.
We conducted this research to investigate the relationship between long intergenic non-protein coding RNA 673 (linc00673) expression and prognosis and clinicopathological parameters in human malignancies.
The PubMed, Embase, WOS, and CNKI databases were used to collect eligible research data before 4 January 2021. Meta-analysis was performed using Stata 12.0 software. Pooled odds ratios (ORs) or hazard ratios (HRs) and their 95% confidence interval (CIs) were calculated to evaluate the association of linc00673 expression with survival outcomes and clinical parameters.
We finally included 17 articles and a total of 1539 cases for the meta-analysis. The results indicated that linc00673 was significantly correlated with T stage (P=0.006), tumor stage (P<0.001), lymph node metastasis (P<0.001), and distant metastasis (P<0.001). In addition, the results suggested that elevated linc00673 expression predicted a poor overall survival (OS) time (P=0.013) and acted as an independent prognostic factor (P<0.001) for OS in patients with malignancy. Although potential evidence of publication bias was found in the studies on OS in relation to tumor stage in the multivariate analysis, the trim-and-fill analysis confirmed that the results remained stable.
Overexpression of linc00673 was significantly correlated with shorter OS time in patients with malignant tumors. Moreover, the increased expression level of linc00673 was significantly correlated with T stage, tumor stage, lymph node metastasis, and distant metastasis. The results presented in this article revealed that linc00673 might be involved in the progression and invasion of malignancy and serve as a novel prognostic biomarker and potential therapeutic target for malignancy.
我们开展此项研究旨在探讨长链非编码 RNA 673（linc00673）表达与人类恶性肿瘤预后和临床病理参数之间的关系。
我们检索了 PubMed、Embase、WOS 和 CNKI 数据库，收集了截至 2021 年 1 月 4 日前发表的相关研究数据。使用 Stata 12.0 软件进行 Meta 分析。计算合并的比值比（OR）或风险比（HR）及其 95%置信区间（CI）来评估 linc00673 表达与生存结局和临床参数之间的关系。
我们最终纳入了 17 项研究，共 1539 例患者进行 Meta 分析。结果表明，linc00673 与 T 分期（P=0.006）、肿瘤分期（P<0.001）、淋巴结转移（P<0.001）和远处转移（P<0.001）显著相关。此外，结果表明，linc00673 高表达预示着总生存（OS）时间较差（P=0.013），并且是恶性肿瘤患者 OS 的独立预后因素（P<0.001）。尽管在多变量分析中，关于肿瘤分期与 OS 的研究中存在潜在的发表偏倚证据，但修剪和填充分析证实结果仍然稳定。
linc00673 的过表达与恶性肿瘤患者的 OS 时间较短显著相关。此外，linc00673 的表达水平升高与 T 分期、肿瘤分期、淋巴结转移和远处转移显著相关。本文的研究结果表明，linc00673 可能参与恶性肿瘤的进展和侵袭，可作为恶性肿瘤的一种新的预后生物标志物和潜在的治疗靶点。
