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长链非编码RNA LINC00673基因变异对糖尿病视网膜病变易感性的影响

Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy.

作者信息

Chuang Chih-Chun, Yang Yi-Sun, Kornelius Edy, Huang Chien-Ning, Hsu Min-Yen, Lee Chia-Yi, Yang Shun-Fa

机构信息

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

Department of Ophthalmology, Changhua Christian Hospital, Changhua, Taiwan.

出版信息

Front Genet. 2022 Apr 25;13:889530. doi: 10.3389/fgene.2022.889530. eCollection 2022.

DOI:10.3389/fgene.2022.889530
PMID:35547254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9081725/
Abstract

Long noncoding RNAs (lncRNAs) have been proven to play critical roles in diabetic retinopathy (DR). This study investigated whether the single nucleotide polymorphism (SNP) of long intergenic noncoding RNA 00673 () affects the clinical characteristics of diabetic retinopathy (DR). A total of three loci of SNPs (rs6501551, rs9914618, and rs11655237) were genotyped using TaqMan allelic discrimination in 276 and 454 individuals with and without DR, respectively. Our results revealed that SNP rs11655237 CT genotype (AOR: 1.592, 95% CI: 1.059-2.395, = 0.026), CT + TT genotype (AOR: 1.255, 95% CI: 1.029-1.531, = 0.025), and allele T (AOR: 1.185, 95% CI: 1.004-1.397, = 0.044) yielded higher ratios in the non-proliferative diabetic retinopathy (NPDR) subgroup than in the non-DR group. Furthermore, the interval of diabetes mellitus (DM) was significantly shorter in the SNP rs11655237 CT + TT variant than that in the SNP rs11655237 wild type (10.44 ± 7.10 vs. 12.98 ± 8.34, = 0.009). In conclusion, the SNP rs11655237 T allele is associated with a higher probability of NPDR development. Patients with the SNP rs11655237 CT + TT variant exhibited a short DM interval.

摘要

长链非编码RNA（lncRNAs）已被证明在糖尿病视网膜病变（DR）中起关键作用。本研究调查了长链基因间非编码RNA00673（）的单核苷酸多态性（SNP）是否影响糖尿病视网膜病变（DR）的临床特征。分别使用TaqMan等位基因鉴别技术对276例和454例患有和未患有DR的个体进行了三个位点的SNP（rs6501551、rs9914618和rs11655237）基因分型。我们的结果显示，SNP rs11655237的CT基因型（优势比：1.592，95%可信区间：1.059 - 2.395，P = 0.026）、CT + TT基因型（优势比：1.255，95%可信区间：1.029 - 1.531，P = 0.025）和等位基因T（优势比：1.185，95%可信区间：1.004 - 1.397，P = 0.044）在非增殖性糖尿病视网膜病变（NPDR）亚组中的比例高于非DR组。此外，SNP rs11655237的CT + TT变异型糖尿病（DM）病程显著短于SNP rs11655237野生型（10.44 ± 7.10 vs. 12.98 ± 8.34，P = 0.009）。总之，SNP rs11655237的T等位基因与NPDR发生的较高概率相关。具有SNP rs11655237 CT + TT变异型的患者DM病程较短。

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Diabetes Metab Syndr Obes. 2021 Oct 13;14:4233-4240. doi: 10.2147/DMSO.S298185. eCollection 2021.
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