Center for Asian Health, Lewis Katz School of Medicine, Temple University, 3440 N. Broad Street, Philadelphia, PA, 19140, USA.
Department of Clinical Sciences, Lewis Katz School of Medicine, Temple University, 3440 N. Broad Street, Philadelphia, PA, 19140, USA.
J Community Health. 2022 Feb;47(1):9-16. doi: 10.1007/s10900-021-01013-z. Epub 2021 Jul 7.
Human papillomavirus (HPV) is the most common sexually transmitted infection in the US. HPV vaccine is a viable source of prevention against high-risk strains that are likely to cause cancer. However, particularly among racial and ethnic minorities such as Chinese Americans, HPV vaccination rates are suboptimal. The goal of this study was to evaluate the effect of a culturally tailored intervention on HPV vaccine uptake in Chinese Americans. We designed and implemented a multilevel longitudinal pilot study to examine the efficacy of the HPV intervention among Chinese American parents/guardians. We recruited 180 participants from federally qualified health center and community-based clinics that serve predominantly low-income Chinese Americans in Philadelphia. Participants were randomized into an intervention group (n = 110) or a control group (n = 70). The intervention group received an HPV specific intervention, while the control group received a general health intervention. The primary outcome was medical record-confirmed receipt of first shot and completion of HPV vaccine within six months of receiving the interventions. Repeated measure ANOVA was utilized to examine the intervention effect on knowledge between intervention and control groups. Knowledge differed significantly, with participants in the intervention group demonstrating the greatest improvement following the intervention. A multivariable logistic regression was used to examine the association between HPV vaccine initiation and study group assignment. There was a significant effect of provider recommendation, parent's gender, and health insurance status on HPV vaccine uptake. This study demonstrated positive impact of a culturally tailored intervention on HPV vaccination uptake among Chinese Americans.
人乳头瘤病毒（HPV）是美国最常见的性传播感染。HPV 疫苗是预防可能导致癌症的高危型HPV 的有效手段。然而，特别是在美国的少数族裔中，如华裔美国人，HPV 疫苗接种率不理想。本研究的目的是评估针对华裔美国人的文化适应性干预对 HPV 疫苗接种率的影响。我们设计并实施了一项多层次纵向试点研究，以检验 HPV 干预措施在华裔美国家长/监护人中的效果。我们从费城的联邦合格健康中心和社区诊所招募了 180 名参与者，这些诊所主要为低收入的华裔美国人提供服务。参与者被随机分为干预组（n=110）和对照组（n=70）。干预组接受 HPV 专项干预，对照组接受一般健康干预。主要结果是医疗记录确认在接受干预后六个月内接种第一针和完成 HPV 疫苗接种。采用重复测量方差分析检验干预组和对照组之间知识的干预效果。知识差异显著，干预组参与者在干预后表现出最大的改善。采用多变量逻辑回归分析研究组分配与 HPV 疫苗接种启动之间的关联。提供者建议、父母性别和医疗保险状况对 HPV 疫苗接种率有显著影响。这项研究表明，文化适应性干预对提高华裔美国人 HPV 疫苗接种率具有积极影响。
