Rosenow U F, Findlay P A, Wright D C
Institut für Medizinische Physik und Biophysik, Universität Göttingen, F.R.G.
Radiother Oncol. 1987 Oct;10(2):127-39. doi: 10.1016/s0167-8140(87)80055-5.
In connection with the development of an optimization method for 125I brain implants in irregularly shaped target volumes, a systematic study was conducted toward optimizing seed configurations for regular target volumes. The intention was to find basic rules for the positioning of strings of seeds in the cylindrical implant pattern of the stereotactic neurosurgical procedure in use, and in accordance with the following criteria: (i) steep dose fall-off outside the target volume; (ii) coverage of the target volume by making the prescribed dose surface coincident with the target volume surface within 1 mm; (iii) uniformity of the dose distribution in the target volume as far as achievable with a seed implant. As a result of this study, an atlas of optimized regular 125I brain implant configurations was compiled. Regular implants were understood as being cylindrical or spherical. Diameters and heights from 2 to 5 cm were covered.
在开发针对不规则形状靶区的¹²⁵I脑植入优化方法的过程中，我们针对规则靶区的籽源配置优化进行了系统研究。目的是找出在所用立体定向神经外科手术的圆柱形植入模式下籽源串定位的基本规则，并符合以下标准：(i)靶区外剂量急剧下降；(ii)通过使规定剂量表面与靶区表面在1毫米内重合来覆盖靶区；(iii)在籽源植入所能达到的范围内使靶区内剂量分布均匀。这项研究的结果是编制了一本优化的¹²⁵I脑规则植入配置图谱。规则植入物被理解为圆柱形或球形。覆盖了直径和高度从2到5厘米的范围。
