Prathap Lavanya, Jayaraman Selvaraj, Roy Anitha, Santhakumar Preetha, Jeevitha M
Department of Anatomy, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamil Nadu, India.
Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai - 600 077, Tamil Nadu, India.
Bioinformation. 2021 Feb 28;17(2):363-368. doi: 10.6026/97320630017363. eCollection 2021.
Inflammation is a process triggered by pro-inflammatory cytokines and anti-inflammatory molecules. Therefore, it is of interest to document the anti-inflammatory activity of Stachydrine and Sakuranetin against the inflammatory target proteins IL-6 and TNF-α by using molecular docking analysis. Both compounds showed good binding features with the selected target proteins. Compared to Sakuranetin, the Stachydrine have low binding energy and good hydrogen bond interactions. Hence, data show that Stachydrine possessed high and specific inhibitory activity on tumor necrosis factor-α and interleukin-6.
炎症是一个由促炎细胞因子和抗炎分子触发的过程。因此，通过分子对接分析来记录水苏碱和樱花素对炎症靶蛋白白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）的抗炎活性是很有意义的。这两种化合物与选定的靶蛋白都显示出良好的结合特性。与樱花素相比，水苏碱具有较低的结合能和良好的氢键相互作用。因此，数据表明水苏碱对肿瘤坏死因子-α和白细胞介素-6具有高度且特异性的抑制活性。
