Zhi Yuan, Gao Ling, Wang Baisheng, Ren Wenhao, Liang Kristina Xiao, Zhi Keqian
Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
Xiangya School of Stomatology, Central South University, Changsha, China.
Front Cell Dev Biol. 2021 Jun 21;9:686906. doi: 10.3389/fcell.2021.686906. eCollection 2021.
Ferroptosis is a newly identified form of regulated cell death that is associated with iron metabolism and oxidative stress. As a physiological mechanism, ferroptosis selectively removes cancer cells by regulating the expression of vital chemical molecules. Current findings on regulation of ferroptosis have largely focused on the function of non-coding RNAs (ncRNAs), especially microRNAs (miRNAs), in mediating ferroptotic cell death, while the sponging effect of circular RNAs (circRNAs) has not been widely studied. In this review, we discuss the molecular regulation of ferroptosis and highlight the value of circRNAs in controlling ferroptosis and carcinogenesis. Herein, we deliberate future role of this emerging form of regulated cell death in cancer therapeutics and predict the progression and prognosis of oncogenesis in future clinical therapy.
铁死亡是一种新发现的受调控的细胞死亡形式，与铁代谢和氧化应激相关。作为一种生理机制，铁死亡通过调节重要化学分子的表达来选择性地清除癌细胞。目前关于铁死亡调控的研究主要集中在非编码RNA（ncRNA），尤其是微小RNA（miRNA）在介导铁死亡细胞死亡中的作用，而环状RNA（circRNA）的海绵作用尚未得到广泛研究。在本综述中，我们讨论了铁死亡的分子调控，并强调了circRNA在控制铁死亡和癌症发生中的价值。在此，我们探讨这种新兴的受调控细胞死亡形式在癌症治疗中的未来作用，并预测未来临床治疗中肿瘤发生的进展和预后。
