Fujihira H, Itoi C, Furukawa S, Kato N, Kashino M
NTT Communication Science Laboratories, Morinosato Wakamiya, Atsugi, Kanagawa, Japan.
Japan Society for the Promotion of Science (JSPS), Kojimachi, Chiyoda-ku, Tokyo, Japan.
Clin Neurophysiol Pract. 2021 Jun 5;6:179-184. doi: 10.1016/j.cnp.2021.04.004. eCollection 2021.
To investigate possible differences in the auditory peripheral and brainstem functions between adults with autism spectrum disorder (ASD) and neurotypical (NT) adults.
Click-evoked auditory brainstem responses (ABRs) were obtained from 17 high-functioning ASD adults (aged 21-38 years) and 20 NT adults (aged 22-36 years). A relatively large number of stimulus presentations (6000) were adopted, and ABRs by horizontal and vertical electrode montages were evaluated, in order to allow precise evaluations of early ABR components.
Waves I, II, III, and V were identified in the vertical electrode montage, and wave I and the summating potential (SP) in electrocochleograms were identified in the horizontal electrode montage. There were no significant group differences in the wave I, II, III, and V latencies or the interpeak latencies (IPLs) in the vertical electrode montage. In the horizontal montage, the ASD adults exhibited significantly shortened SP latencies compared with the NT adults, whereas there was no significant group difference in the wave I latency.
The ASD adults may have the abnormalities of processing more in the peripheral auditory system than in the brainstem.
The current study suggests that the peripheral abnormality is associated with ASD.
探讨自闭症谱系障碍（ASD）成人与神经典型（NT）成人在听觉外周和脑干功能方面可能存在的差异。
对17名高功能ASD成人（年龄21 - 38岁）和20名NT成人（年龄22 - 36岁）进行短声诱发的听觉脑干反应（ABR）测试。采用相对大量的刺激呈现次数（6000次），并评估水平和垂直电极蒙太奇记录的ABR，以便精确评估早期ABR成分。
在垂直电极蒙太奇记录中识别出波I、II、III和V，在水平电极蒙太奇记录中识别出波I和耳蜗电图中的总和电位（SP）。垂直电极蒙太奇记录中，波I、II、III和V的潜伏期以及峰间潜伏期（IPL）在两组间无显著差异。在水平蒙太奇记录中，与NT成人相比，ASD成人的SP潜伏期显著缩短，而波I潜伏期在两组间无显著差异。
ASD成人可能在外周听觉系统而非脑干中的处理存在更多异常。
当前研究表明外周异常与ASD相关。
