Zieve L, Olsen R L
Gut. 1977 Sep;18(9):688-91. doi: 10.1136/gut.18.9.688.
Intraventricular infusions of octopamine which raised brain octopamine concentrations more than 20 000-fold resulted in reductions in brain noradrenaline and dopamine by as much as 90% without affecting the alertness or activity of normal rats. As this reduction of brain catecholamines is much greater than any reported in hepatic coma, we do not believe that values observed in experimental hepatic failure have aetiological significance for the encephalopathy that ensues.
脑室内注入章鱼胺可使脑内章鱼胺浓度升高超过20000倍，导致脑内去甲肾上腺素和多巴胺减少多达90%，而不影响正常大鼠的警觉性或活动。由于这种脑内儿茶酚胺的减少比肝昏迷中报道的任何减少都要大得多，我们认为在实验性肝衰竭中观察到的值对随后发生的肝性脑病没有病因学意义。
