Department of Cardiology, University of Health Sciences, Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Trabzon, Turkey.
Angiology. 2022 Feb;73(2):120-124. doi: 10.1177/00033197211028780. Epub 2021 Jul 8.
The most common cause of complete atrioventricular block (CAVB) is age-related fibrotic degeneration and is referred to as primary idiopathic complete atrioventricular block (iCAVB). This study aims to investigate the relationship between iCAVB and arterial stiffness using the cardio-ankle vascular index (CAVI).In this study, of 205 CAVB patients, 41 patients with iCAVB implanted with a dual-chamber permanent pacemaker and 40 age- and gender-matched controls were studied. Arterial stiffness was assessed by a VaSera VS-1000 CAVI instrument. The CAVI values of patients with iCAVB were significantly higher compared with the controls (9.63 ± 1.42 vs 8.57 ± 1.12, < .001). Idiopathic complete atrioventricular block frequency was higher among patients with abnormal CAVI values than those with borderline and normal CAVI ( = .04). In multivariate analysis, only CAVI was an independent predictor of iCAVB after adjusting for other relevant factors (odds ratio, 2.575; 95% CI [1.390-4.770]; = .003). The present study demonstrated that CAVI, as a marker of arterial stiffness, was increased among elderly patients with iCAVB. Thus, we provide a possible additional mechanism linking easily measured CAVI with iCAVB.
最常见的完全性房室传导阻滞（CAVB）的原因是与年龄相关的纤维化变性，称为原发性特发性完全性房室传导阻滞（iCAVB）。本研究旨在使用脉波传导速度（CAVI）来探讨 iCAVB 与动脉僵硬度之间的关系。
在这项研究中，对 205 例 CAVB 患者进行了研究，其中 41 例 iCAVB 患者植入了双腔永久起搏器，40 例年龄和性别匹配的对照者。采用 VaSera VS-1000 CAVI 仪器评估动脉僵硬度。与对照组相比，iCAVB 患者的 CAVI 值明显更高（9.63 ± 1.42 比 8.57 ± 1.12， <.001）。CAVI 值异常的患者中，特发性完全性房室传导阻滞的发生率高于边界值和正常 CAVI 值的患者（ =.04）。在多变量分析中，仅 CAVI 在调整其他相关因素后是 iCAVB 的独立预测因子（优势比，2.575；95%置信区间[1.390-4.770]； =.003）。本研究表明，CAVI 作为动脉僵硬度的标志物，在患有 iCAVB 的老年患者中增加。因此，我们提供了一个可能的额外机制，将易于测量的 CAVI 与 iCAVB 联系起来。
