Wang Meng-Hui, Fang Hui, Xie Chuan
Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, The Jiangxi Medical College, The Nanchang University, Nanchang 330006, Jiangxi Province, China.
World J Clin Oncol. 2024 Sep 24;15(9):1117-1121. doi: 10.5306/wjco.v15.i9.1117.
In this editorial, we delve into the article and offer valuable insights into a crucial aspect of gastric cancer aetiology. Gastric cancer is a malignancy emanating from the epithelial lining of the gastric mucosa and one of the most prevalent forms of cancer worldwide. The development of gastric cancer is associated with multiple risk factors, including infection, advanced age, a diet rich in salt, and suboptimal eating patterns. Despite notable reductions in morbidity and mortality rates, gastric cancer remains a formidable public health concern, impacting patients' lives. Advanced glycation end products (AGEs) are complex compounds arising from nonenzymatic reactions within living organisms, the accumulation of which is implicated in cellular and tissue damage; thus, the levels are AGEs are correlated with the risk of diverse diseases. The investigation of AGEs is of paramount importance for the treatment of gastric cancer and can provide pivotal insights into disease pathogenesis and preventive and therapeutic strategies. The reduction of AGEs levels and suppression of their accumulation are promising avenues for mitigating the risk of gastric cancer. This approach underscores the need for further research aimed at identifying innovative interventions that can effectively lower the incidence and mortality rates of this malignancy.
在这篇社论中，我们深入探讨了这篇文章，并对胃癌病因学的一个关键方面提供了有价值的见解。胃癌是一种起源于胃黏膜上皮的恶性肿瘤，是全球最常见的癌症形式之一。胃癌的发生与多种风险因素有关，包括感染、高龄、高盐饮食和不良饮食习惯。尽管发病率和死亡率显著下降，但胃癌仍然是一个严峻的公共卫生问题，影响着患者的生活。晚期糖基化终末产物（AGEs）是生物体内非酶促反应产生的复杂化合物，其积累与细胞和组织损伤有关；因此，AGEs水平与多种疾病的风险相关。对AGEs的研究对于胃癌的治疗至关重要，可为疾病发病机制以及预防和治疗策略提供关键见解。降低AGEs水平并抑制其积累是降低胃癌风险的有前景的途径。这种方法强调了进一步开展研究的必要性，旨在确定能够有效降低这种恶性肿瘤发病率和死亡率的创新干预措施。
