巴基斯坦儿童败血症患者中广泛耐药伤寒和碳青霉烯类耐药病原体的分子检测——公共卫生关注点。
Molecular detection of extensively drug-resistant Typhi and carbapenem-resistant pathogens in pediatric septicemia patients in Pakistan - a public health concern.
机构信息
Department of Microbiology, Faculty of Life Sciences, Government College University Faisalabad, 38000, Pakistan.
Department of Pathology, Fatima Memorial Hospital, Lahore, 54000, Pakistan.
出版信息
Future Microbiol. 2021 Jul;16:731-739. doi: 10.2217/fmb-2021-0036. Epub 2021 Jul 8.
To determine the prevalence of multidrug (MDR) and extensively drug-resistant (XDR) pathogens from pediatric blood samples In total, 4543 children's blood samples were processed in the BacT/ALERT system. Confirmation of the isolates and MIC was determined in VITEK 2 system. Molecular identification of , and was done by PCR. Of 4543 blood cultures, 458 (10%) were positive for bacterial growth and Typhi (415; 90%) remained the primary pathogens. Antibiogram revealed 208 (50.1%) and 137 (33%) were MDR and XDR . Typhi, respectively. displayed 46% resistance to imipenem. One hundred twelve (81.7%) XDR Typhi were positive for , whereas 14 (66.6%) were found in carbapenem-resistant bacteria. A high prevalence of MDR and XDR pathogens was found in peads blood culture.
为了确定儿科血液样本中耐多药（MDR）和广泛耐药（XDR）病原体的流行情况，共对 4543 份儿童血液样本进行了 BacT/ALERT 系统处理。在 VITEK 2 系统中确定了分离物和 MIC 的确认。通过 PCR 进行了 、 和 的分子鉴定。在 4543 份血培养物中，有 458 份（10%）呈细菌生长阳性， 伤寒（415；90%）仍然是主要病原体。抗生素谱显示 208 株（50.1%）和 137 株（33%）分别为 MDR 和 XDR 伤寒。 对亚胺培南的耐药性为 46%。112 株（81.7%）XDR 伤寒对 呈阳性，而 14 株（66.6%）则存在于耐碳青霉烯类药物的细菌中。在儿科血液培养物中发现了耐多药和广泛耐药病原体的高流行率。
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