Purice S, Tudor A, Gheorghiu M, Matei I, Baltă M, Cojocaru M, Pecec C
N. Gh. Lupu Institute of Internal Medicine, Bucharest, Romania.
Med Interne. 1987 Oct-Dec;25(4):227-32.
In the course of an ample study of collagen diseases carried out in the "N. Gh. Lupu" Institute of Internal Medicine--Bucharest over a long period, a group of 608 patients with systemic lupus erythematosus (SLE) hospitalized between 1974 and 1986 formed the object of the present study. Of these patients 18% presented pulmonary alterations due to SLE and 3.9% lung diseases of other etiology. The types of pulmonary involvement due to SLE were: pleurisy, interstitial pneumonia, diaphragmatic myopathy. Latent pulmonary damage could also be diagnosed in 8 patients. Most of the patients (94.1%) were females and had been hospitalized several times. Concomitantly with pulmonary damage other organ involvements have also been observed. Complex investigation of respiratory function performed in a selected group of patients revealed: restrictive syndrome, decrease of the gas transfer factor, increase of elastic recoil, hypoxemia on exercise. In most of the cases (92%) the pulmonary diseases had a chronic evolution. The treatment used was corticosteroids in 60% of the cases investigated.
在布加勒斯特“N. Gh. 卢普”内科研究所长期开展的对胶原病的广泛研究过程中，本研究以1974年至1986年间住院的608例系统性红斑狼疮（SLE）患者为对象。这些患者中，18%出现了由SLE引起的肺部改变，3.9%患有其他病因的肺部疾病。SLE引起的肺部受累类型包括：胸膜炎、间质性肺炎、膈肌肌病。另外还在8例患者中诊断出潜在的肺部损害。大多数患者（94.1%）为女性，且已多次住院。除肺部损害外，还观察到了其他器官受累情况。对部分选定患者进行的呼吸功能综合检查显示：限制性综合征、气体交换因子降低、弹性回缩增加、运动时低氧血症。在大多数病例（92%）中，肺部疾病呈慢性进展。在60%的受调查病例中使用的治疗方法为皮质类固醇。
