Breast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Department of Surgical Oncology, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan.
Sci Rep. 2021 Jul 8;11(1):14134. doi: 10.1038/s41598-021-93681-z.
Advanced gastric cancer (GC) is one of the most lethal cancer types, thus a better understanding of its biology in patients is urgently needed. MicroRNA (miR)-29a is a known tumor suppressive miR that is related to metastasis, but its clinical relevance in GC remains ambiguous. Here, using a large GC patient cohort we hypothesized that low expression of miR-29a in GC is associated with aggressive cancer biology and worse survival. We demonstrated that low miR-29a GC enriched cell proliferation, apoptosis, metastasis, and angiogenesis related gene sets, as well as the higher expression of related genes. Low miR-29a GC was associated with less anti-cancer immune cell infiltration as well as immune related scoring. Low miR-29a GC demonstrated a worse overall survival (OS) as well as disease specific survival (DSS) compared with high expressing miR-29a GC. Notably, low miR-29a expression was the only factor, other than residual tumor status, to be an independent prognostic biomarker of worse OS and DSS. In conclusion, low miR-29a GC was associated with aggressive cancer biology and worse OS as well as DSS. Additionally, low expression of miR-29a was an independent prognostic biomarker of OS and DSS in gastric cancer patients.
晚期胃癌（GC）是最致命的癌症类型之一，因此迫切需要更好地了解患者的生物学特性。microRNA（miR）-29a 是一种已知的肿瘤抑制 miR，与转移有关，但在 GC 中的临床相关性尚不清楚。在这里，我们使用一个大型 GC 患者队列假设 GC 中 miR-29a 的低表达与侵袭性癌症生物学和较差的生存相关。我们证明了低 miR-29a GC 富集了与细胞增殖、凋亡、转移和血管生成相关的基因集，以及相关基因的更高表达。低 miR-29a GC 与较少的抗癌免疫细胞浸润以及免疫相关评分相关。与高表达 miR-29a 的 GC 相比，低 miR-29a GC 的总生存期（OS）和疾病特异性生存期（DSS）更差。值得注意的是，低 miR-29a 表达是除残留肿瘤状态外唯一独立的预后生物标志物，与较差的 OS 和 DSS 相关。总之，低 miR-29a GC 与侵袭性癌症生物学和较差的 OS 以及 DSS 相关。此外，miR-29a 的低表达是胃癌患者 OS 和 DSS 的独立预后生物标志物。
