与长期服用对乙酰氨基酚相关的急性肝功能障碍
Acute Hepatic Dysfunction Related to Chronic Acetaminophen Administration.
作者信息
Rootring Ellen, Sargel Cheryl L, Tobias Joseph D
出版信息
J Pediatr Pharmacol Ther. 2021;26(5):497-501. doi: 10.5863/1551-6776-26.5.497. Epub 2021 Jun 28.
Abstract
Toxicity related to acetaminophen is most encountered with the acute ingestion of large doses. However, toxicity may also result from chronic ingestion, even when recommended doses are administered over a prolonged period of time. We present the case of a 20-month-old female toddler who received therapeutic recommended doses of acetaminophen (oral or intravenous) following multiple surgical interventions for treatment of a tracheo-esophageal fistula following ingestion of a button battery. The potential role of chronic acetaminophen administration in the etiology of hepatoxicity is discussed and prevention strategies are presented.
摘要
对乙酰氨基酚相关的毒性最常发生于大剂量急性摄入时。然而，即使在长时间服用推荐剂量的情况下，慢性摄入也可能导致毒性。我们报告一例20个月大的女幼儿病例，该患儿在因误吞纽扣电池接受气管食管瘘多次手术治疗后，接受了治疗推荐剂量的对乙酰氨基酚（口服或静脉注射）。本文讨论了长期服用对乙酰氨基酚在肝毒性病因中的潜在作用，并提出了预防策略。
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