Kediso Teketel Eristu, Tolessa Tesfaye, Getachew Fikirte, Makonnen Eyasu, Seifu Daniel
Department of Biomedical Sciences, College of Health Sciences, Arbaminch University, Arbaminch, Ethiopia.
Department of Physiology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Evid Based Complement Alternat Med. 2021 Jun 17;2021:6690965. doi: 10.1155/2021/6690965. eCollection 2021.
(Jacq. ex Willd.), commonly called African wormwood, is a highly aromatic perennial herb and a well-known medicinal plant, claimed to be effective and safe in the treatment of epilepsy. The whole-plant extract is traditionally used as an antiepileptic agent in Ethiopia. . The aim of this study was, therefore, to evaluate the anticonvulsant effect of the hydroethanolic extract and solvent fractions of whole part in mice.
The effects of hydroethanolic extract and its solvent fractions were evaluated against pentylenetetrazole- (PTZ-) induced convulsions in mice. The onset and duration of PTZ-induced convulsions were determined with hydroethanolic extract and its solvent fractions. Data were analyzed using a one-way analysis of variance (ANOVA) followed by post hoc Tukey's multiple comparisons test. < 0.05 was considered statistically significant.
The hydroethanolic extract of with all the three doses of 250, 500, and 1000 mg/kg, showed a significant delay (504.833 ± 62.835 s; < 0.05 ; 551.833 ± 47.69 s; < 0.01 ; and 808.333 ± 64.8 s; < 0.001 , respectively) in the mean onset of convulsion and a decrease (17.000 ± 1.88 s, < 0.05 ; 13.000 ± 1.8 s, < 0.01 ; and 7.833 ± 1.07 s, < 0.001, respectively) in the mean duration of convulsion against PTZ-induced convulsion in a dose-dependent manner compared to the control (92.833 ± 13.006 s; 34.167 ± 3.683 s), and its anticonvulsant activity was significantly less compared to that of diazepam (1001.167 ± 68.430 s; 4.500 ± 0.619 s). The solvent fractions, however, did not show anticonvulsant activity against PTZ-induced convulsion.
Crude extract of has an anticonvulsant effect in mice. This might be attributed to the synergistic effects of two or more active ingredients present in the herb.
（Jacq. ex Willd.），通常被称为非洲苦艾，是一种具有高度芳香的多年生草本植物，也是一种著名的药用植物，据称在治疗癫痫方面有效且安全。在埃塞俄比亚，全株提取物传统上被用作抗癫痫药物。因此，本研究的目的是评估全株乙醇提取物及其溶剂提取物对小鼠的抗惊厥作用。
评估乙醇提取物及其溶剂提取物对小鼠戊四氮（PTZ）诱导惊厥的影响。用乙醇提取物及其溶剂提取物测定PTZ诱导惊厥的发作时间和持续时间。数据采用单因素方差分析（ANOVA），随后进行事后Tukey多重比较检验。P < 0.05被认为具有统计学意义。
与对照组（92.833 ± 13.006秒；34.167 ± 3.683秒）相比，250、500和1000 mg/kg三个剂量的乙醇提取物均显著延迟了惊厥的平均发作时间（分别为504.833 ± 62.835秒，P < 0.05；551.833 ± 47.69秒，P < 0.01；808.333 ± 64.8秒，P < 0.001），并剂量依赖性地缩短了惊厥的平均持续时间（分别为17.000 ± 1.88秒，P < 0.05；13.000 ± 1.8秒，P < 0.01；7.833 ± 1.07秒，P < 0.001），其抗惊厥活性与地西泮（1001.167 ± 68.430秒；4.500 ± 0.619秒）相比明显较低。然而，溶剂提取物对PTZ诱导的惊厥没有显示出抗惊厥活性。
全株粗提取物对小鼠有抗惊厥作用。这可能归因于该草药中两种或更多活性成分的协同作用。
