不同强度运动对肥胖大鼠组织损伤及基因表达的影响。
Effects of different intensity of exercise on tissue injury and gene expression in obese rats.
作者信息
Wu Shujia, Zhang Cheng, Xu Feng, Li Ke, Li Anke, Wu Junzhu
机构信息
Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Wuhan University Wuhan 430072, China.
Center for Experimental Teaching of Basic Medical Science, School of Basic Medical Science, Wuhan University Wuhan 430072, China.
出版信息
Int J Clin Exp Pathol. 2021 Jun 15;14(6):705-712. eCollection 2021.
Weight loss is an important aspect of chronic disease prevention and management, with increasing rates of overweight and obesity worldwide. Drugs and surgery are popular approaches to lose weight. Given their potential harm to the body, exercise is an alternative widely accepted approach. However, participation in high intensity exercise entails an inherent risk of sports-related injuries. In this study, a rat model fed with high fat diet was employed to investigate the effects of different intensity of exercise prescription on both weight loss and tissue injury after exercise and to find a proper exercise prescription for losing weight with minimal tissues injuries. We inferred that 3% weight bearing might be the proper exercise prescription for high fat diet-fed rats in our experimental setting.
随着全球超重和肥胖率的上升，体重减轻是慢性病预防和管理的一个重要方面。药物和手术是常见的减肥方法。鉴于它们对身体的潜在危害，运动是一种被广泛接受的替代方法。然而，参与高强度运动存在与运动相关损伤的固有风险。在本研究中，采用高脂饮食喂养的大鼠模型，研究不同强度运动处方对运动后体重减轻和组织损伤的影响，并寻找一种能使组织损伤最小的合适减肥运动处方。我们推断，在我们的实验环境中，3%负重可能是高脂饮食喂养大鼠的合适运动处方。
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