Sakamoto Risa, Hamahiro Tomoka, Maeda Ryo, Ayabe Takanori, Tomita Masaki, Tanaka Hiroyuki
Department of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
J Surg Case Rep. 2021 Jul 6;2021(7):rjab283. doi: 10.1093/jscr/rjab283. eCollection 2021 Jul.
We report a rare case of recurrent solitary fibrous tumor (SFT) of the pleura with suspicious malignant transformation. A 78-year-old man had undergone prior surgical resection of the primary and recurrent SFT tumors at 11 and 2 years before the current presentation. Although his primary tumor had a round shape and did not show invasive growth, the current recurrent tumor extended through the neural foramen and had an osteoclastic progression into the thoracic spine. A computed tomography (CT) guided needle biopsy was performed and the pathological diagnosis of the tumor was confirmed as the recurrence of SFT. Immunohistochemically, the MIB-1 proliferation index (Ki-67) of the primary tumor and the current tumor was 1.74 and 30.00%, respectively. These clinical and immunohistochemical findings were strongly suspected the malignant transformation of SFT from benign. He was treated with radiotherapy, and a response was observed.
我们报告一例罕见的复发性胸膜孤立性纤维瘤（SFT），伴有可疑的恶性转化。一名78岁男性在本次就诊前11年和2年曾接受过原发性和复发性SFT肿瘤的手术切除。尽管其原发性肿瘤呈圆形且未表现出浸润性生长，但当前的复发性肿瘤通过神经孔扩展，并呈破骨样进展至胸椎。进行了计算机断层扫描（CT）引导下的针吸活检，肿瘤的病理诊断被确认为SFT复发。免疫组化显示，原发性肿瘤和当前肿瘤的MIB-1增殖指数（Ki-67）分别为1.74%和30.00%。这些临床和免疫组化结果强烈怀疑SFT已从良性发生恶性转化。他接受了放射治疗，并观察到有反应。
