Ozturk Erman
Istanbul Medeniyet University Faculty of Medicine, Department of Hematology, Istanbul, Turkey.
Medeni Med J. 2021;36(2):146-151. doi: 10.5222/MMJ.2021.91145. Epub 2021 Jun 18.
Hypocholesterolemia is a metabolism disorder that may be seen in chronic diseases and malignancies. Various dyslipidemia profiles have been shown in adult and pediatric hematological malignancies. We aimed to evaluate the lipid profile properties in patients diagnosed with a hematological malignancy compared to a healthy control group.
Out of 1213 patients diagnosed with hematologic malignancy, the data of 98 patients whose pretreatment lipid profiles had already been studied, were reviewed. Forty healthy individuals were selected as the control group. The levels of total cholesterol, triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were compared.
Triglyceride values were significantly higher (p=0.02), and the total cholesterol, LDL and HDL levels were lower in the study group compared to the control group. Triglyceride values were higher (p=0.013), and HDL levels were lower (p=0.022) in parallel with increases in uric acid levels. There was a significant correlation between the International Prognostic Index (IPI) score and TG (p=0.003) in those diagnosed with non-Hodgkin lymphoma (NHL). Whereas no significant correlation was found between TG, total cholesterol, and LDL values in the limited (early) and advanced stage NHL, while a significant negative correlation was found with HDL (p=0.027).
Hypertriglyceridemia, as well as low LDL and HDL values may be seen in hematological malignancies. It should be kept in mind that there may be chronic diseases and malignancies in the etiology of incidental hypocholesterolemia and hypertriglyceridemia. Further studies are needed on this subject to determine the effects of dyslipidemia on the pathogenesis and prognosis of the disease in hematological malignancies.
低胆固醇血症是一种代谢紊乱，可见于慢性疾病和恶性肿瘤。成人和儿童血液系统恶性肿瘤已显示出各种血脂异常情况。我们旨在评估与健康对照组相比，被诊断为血液系统恶性肿瘤患者的血脂谱特征。
在1213例被诊断为血液系统恶性肿瘤的患者中，回顾了98例其治疗前血脂谱已被研究的患者的数据。选择40名健康个体作为对照组。比较总胆固醇、甘油三酯（TG）、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）水平。
与对照组相比，研究组的甘油三酯值显著更高（p = 0.02），总胆固醇、LDL和HDL水平更低。随着尿酸水平升高，甘油三酯值更高（p = 0.013），HDL水平更低（p = 0.022）。在非霍奇金淋巴瘤（NHL）患者中，国际预后指数（IPI）评分与TG之间存在显著相关性（p = 0.003）。而在局限性（早期）和晚期NHL中，TG、总胆固醇和LDL值之间未发现显著相关性，而与HDL存在显著负相关（p = 0.027）。
血液系统恶性肿瘤患者可能出现高甘油三酯血症以及低LDL和HDL值。应牢记，偶发性低胆固醇血症和高甘油三酯血症的病因中可能存在慢性疾病和恶性肿瘤。关于这一主题需要进一步研究，以确定血脂异常对血液系统恶性肿瘤疾病发病机制和预后的影响。
