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影响脂质代谢和血管健康的血液学药物

Haematological Drugs Affecting Lipid Metabolism and Vascular Health.

作者信息

Parrella Antonio, Iannuzzi Arcangelo, Annunziata Mario, Covetti Giuseppe, Cavallaro Raimondo, Aliberti Emilio, Tortori Elena, Iannuzzo Gabriella

机构信息

Department of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.

Hematology Unit, A. Cardarelli Hospital, 80131 Naples, Italy.

出版信息

Biomedicines. 2022 Aug 10;10(8):1935. doi: 10.3390/biomedicines10081935.

Abstract

Many drugs affect lipid metabolism and have side effects which promote atherosclerosis. The prevalence of cancer-therapy-related cardiovascular (CV) disease is increasing due to development of new drugs and improved survival of patients: cardio-oncology is a new field of interest and research. Moreover, drugs used in transplanted patients frequently have metabolic implications. Increasingly, internists, lipidologists, and angiologists are being consulted by haematologists for side effects on metabolism (especially lipid metabolism) and arterial circulation caused by drugs used in haematology. The purpose of this article is to review the main drugs used in haematology with side effects on lipid metabolism and atherosclerosis, detailing their mechanisms of action and suggesting the most effective therapies.

摘要

许多药物会影响脂质代谢并具有促进动脉粥样硬化的副作用。由于新药的研发和患者生存率的提高,癌症治疗相关心血管疾病的患病率正在上升:心脏肿瘤学是一个新的关注和研究领域。此外,移植患者使用的药物常常具有代谢方面的影响。血液科医生越来越多地就血液学中使用的药物对代谢(尤其是脂质代谢)和动脉循环产生的副作用向内科医生、脂质学家和血管病学家咨询。本文的目的是综述血液学中使用的对脂质代谢和动脉粥样硬化有副作用的主要药物,详细阐述其作用机制并提出最有效的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9567/9405726/7d27238dfbb7/biomedicines-10-01935-g001.jpg

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