Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan.
Medical and Natural Sciences Research Centre, University of Tubingen, Germany.
Clin Chim Acta. 2015 Apr 15;444:43-9. doi: 10.1016/j.cca.2015.01.038. Epub 2015 Feb 11.
Previous studies appreciate the leukemia-associated alterations in plasma lipid profiles but fail to provide a consistent pattern of lipid anomalies in leukemia patients. These inconsistencies could be due to overlooking the effects of related confounding risk-factors and comorbidities.
The plasma lipid profiles of acute-leukemia and control groups were compared.
We observed that acute lymphocytic leukemia (ALL) patients display significantly higher triglycerides and very low-density lipoproteins, whereas, acute myeloid leukemia (AML) patients display significantly lower high-density lipoproteins. To assess the confounding effects of related risk factors gender-, age- and BMI-based analyses were performed. We observed that the aforementioned significant differences in the lipid profiles of leukemia patients were restricted to female participants of the respective groups. Moreover, a significant decrease in total cholesterol and low-density lipoprotein levels was observed only in male participants of the AML population. Various age-specific trends in plasma lipid profile of the leukemia patients were also observed. BMI-based analysis did not display many significant differences from the overall analyses. In addition to comparing the absolute values of plasma lipids in leukemia and control groups we also compared and observed significant differences in prevalence of various isolated- and mixed-dyslipidemias in these groups.
These findings may help in outlining the prevalence and types of dyslipidemia in leukemia patients that may emerge as diagnostic/prognostic factors for the management of acute leukemia.
先前的研究表明，血浆脂质谱在白血病中有变化，但未能为白血病患者提供一致的脂质异常模式。这些不一致可能是由于忽视了相关混杂风险因素和合并症的影响。
比较了急性白血病组和对照组的血浆脂质谱。
我们观察到急性淋巴细胞白血病（ALL）患者的甘油三酯和极低密度脂蛋白明显升高，而急性髓系白血病（AML）患者的高密度脂蛋白明显降低。为了评估相关风险因素的混杂影响，进行了基于性别、年龄和 BMI 的分析。我们观察到，上述白血病患者脂质谱的显著差异仅局限于相应组别的女性参与者。此外，仅在 AML 人群的男性参与者中观察到总胆固醇和低密度脂蛋白水平的显著降低。还观察到白血病患者的血浆脂质谱存在各种年龄特异性趋势。基于 BMI 的分析与总体分析相比没有显示出许多显著差异。除了比较白血病组和对照组的血浆脂质绝对值外，我们还比较了这些组中各种孤立性和混合性血脂异常的患病率，并观察到了显著差异。
这些发现可能有助于概述白血病患者血脂异常的患病率和类型，这些异常可能成为急性白血病管理的诊断/预后因素。
