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[冰人:对冰川木乃伊“奥茨”30年研究的生活场景与病理发现]

[The Iceman : Life scenarios and pathological findings from 30 years of research on the glacier mummy "Ötzi"].

作者信息

Nerlich Andreas G, Egarter Vigl Eduard, Fleckinger Angelika, Tauber Martina, Peschel Oliver

机构信息

Institut für Pathologie, Klinikum Bogenhausen, München Klinik gGmbH, Englschalkingerstr. 77, 81925, München, Deutschland.

Landesfachhochschule für Gesundheitsberufe "Claudiana", Bozen, Italien.

出版信息

Pathologe. 2021 Sep;42(5):530-539. doi: 10.1007/s00292-021-00961-6. Epub 2021 Jul 8.

DOI:10.1007/s00292-021-00961-6
PMID:34240239
Abstract

The comprehensive investigation of the excellently preserved mummy of Ötzi, the Iceman, and his equipment over the last 30 years has provided a wealth of information about the life and disease of this late Neolithic individual. This research has indicated that his origin was from a local southern Alpine population, that he grew up in the valleys of the Southern Alps, and that he had considerable local mobility. He had well-balanced nutrition with a mixed vegetable and animal diet. He was very mobile in the alpine terrain and of athletic constitution. The Iceman suffered from mild to moderate degenerative joint disease primarily of the right hip joint, slight spondylosis of the cervical and lumbar spine, a minor focal (premature) arteriosclerosis, lung anthracosis and possibly silicosis, previous pleuritic inflammation (possibly of post-specific origin), intestinal infections of the stomach by Helicobacter pylori and Trichuris trichiura worm infestation in the intestines, a mild osteomalacia of cancellous bone, and diverse pathologies of his teeth with dental caries and periodontitis, as well as hair anomalies. The presence of borreliosis is still under debate. As potential remedies, the Iceman carried some anthelmintic substances with him: a birch polypore and an anthelmintic fern. The numerous tattoos may also have had therapeutic effects. Finally, the last days of Ötzi could be reconstructed quite precisely: his gastrointestinal content indicates that the Iceman moved from Alpine heights to a lower location and then again up to the glacier region where he died. During this journey he encountered two attacks: the first, several days before his death, lead to a stabbing wound in his right hand; the second was an arrow hit that wounded the Iceman lethally at his left axilla by laceration of the subclavian artery.

摘要

在过去30年里,对保存极为完好的冰人奥茨及其装备进行的全面研究,为我们提供了大量关于这位新石器时代晚期个体的生活与疾病的信息。这项研究表明,他起源于阿尔卑斯山南部的当地人群,在南阿尔卑斯山的山谷中长大,并且在当地有相当大的活动范围。他的营养均衡,饮食包含蔬菜和肉类。他在高山地形中活动频繁,体格健壮。冰人患有轻度至中度的退行性关节疾病,主要累及右髋关节,颈椎和腰椎有轻微的脊柱关节病,有轻微的局灶性(过早)动脉硬化、肺煤尘沉着病以及可能的矽肺病,曾有胸膜炎炎症(可能是特异性感染后所致),胃部有幽门螺杆菌引起的肠道感染以及肠道有鞭虫感染,松质骨有轻度骨软化症,牙齿有多种病变,包括龋齿和牙周炎,还有毛发异常。莱姆病是否存在仍存在争议。作为潜在的治疗手段,冰人随身携带了一些驱虫物质:桦褐孔菌和一种驱虫蕨类植物。众多的纹身可能也有治疗作用。最后,奥茨生命的最后几天能够相当精确地被重建:他胃肠道的内容物表明,冰人从高山高处转移到较低位置,然后又回到他死亡的冰川区域。在这段旅程中,他遭遇了两次袭击:第一次,在他去世前几天,导致他右手有一处刺伤;第二次是被箭射中,箭伤致使他左腋窝下的锁骨下动脉撕裂,最终致命。

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New glacier evidence for ice-free summits during the life of the Tyrolean Iceman.新的冰川证据表明,在蒂罗尔冰人生活的时期,山顶没有冰。
Sci Rep. 2020 Dec 17;10(1):20513. doi: 10.1038/s41598-020-77518-9.
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Rofo. 2018 Jan;190(1):61-64. doi: 10.1055/s-0043-119890. Epub 2017 Nov 3.
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The history of Helicobacter pylori: from phylogeography to paleomicrobiology.幽门螺杆菌的历史:从系统地理学到古微生物学。
Clin Microbiol Infect. 2016 Nov;22(11):922-927. doi: 10.1016/j.cmi.2016.07.013. Epub 2016 Jul 21.
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The 5300-year-old Helicobacter pylori genome of the Iceman.冰人的有5300年历史的幽门螺杆菌基因组。
Science. 2016 Jan 8;351(6269):162-165. doi: 10.1126/science.aad2545.
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Population genomic analysis of ancient and modern genomes yields new insights into the genetic ancestry of the Tyrolean Iceman and the genetic structure of Europe.对古代和现代基因组的群体基因组分析为提洛尔冰人的遗传谱系以及欧洲的遗传结构带来了新的见解。
PLoS Genet. 2014 May 8;10(5):e1004353. doi: 10.1371/journal.pgen.1004353. eCollection 2014 May.
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Scalable metagenomic taxonomy classification using a reference genome database.基于参考基因组数据库的可扩展宏基因组分类学分类。
Bioinformatics. 2013 Sep 15;29(18):2253-60. doi: 10.1093/bioinformatics/btt389. Epub 2013 Jul 4.
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Paleoproteomic study of the Iceman's brain tissue.古蛋白组学研究“冰人”脑组织。
Cell Mol Life Sci. 2013 Oct;70(19):3709-22. doi: 10.1007/s00018-013-1360-y. Epub 2013 Jun 6.
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Oral pathologies of the Neolithic Iceman, c.3,300 BC.公元前约3300年新石器时代冰人的口腔病理学
Eur J Oral Sci. 2013 Jun;121(3 Pt 1):137-41. doi: 10.1111/eos.12037. Epub 2013 Apr 9.
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The musculoskeletal abnormalities of the Similaun Iceman ("ÖTZI"): clues to chronic pain and possible treatments.《西蒙勒冰人(“奥茨”)的肌肉骨骼异常:慢性疼痛的线索和可能的治疗方法》。
Inflammopharmacology. 2013 Feb;21(1):11-20. doi: 10.1007/s10787-012-0153-5. Epub 2012 Oct 25.
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Nanostructure and mechanics of mummified type I collagen from the 5300-year-old Tyrolean Iceman.来自 5300 年前的蒂罗尔冰人的木乃伊化 I 型胶原的纳米结构和力学特性。
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